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1.A.72.1.1
The MerF mercuric ion uptake transporter

Accession Number:Q56446
Protein Name:MerF aka MERT
Length:81
Molecular Weight:8726.00
Species:Pseudomonas fluorescens, OS Xanthomonas sp., OS Comamonas testosteroni (Pseudomonas testosteroni), OS Citrobacter freundii, and OS Escherichia coli [582]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Hg2+

Cross database links:

Pfam: PF11431   

References (7)

[1] “Mercury resistance determinants related to Tn21, Tn1696, and Tn5053 in enterobacteria from the preantibiotic era.”  Essa A.M.et.al.   12604550
[2] “Four genes, two ends, and a res region are involved in transposition of Tn5053: a paradigm for a novel family of transposons carrying either a mer operon or an integron.”  Kholodii G.Y.et.al.   8594337
[3] “NMR structure determination of a membrane protein with two transmembrane helices in micelles: MerF of the bacterial mercury detoxification system.”  Howell S.C.et.al.   15794657
[4] “Mercury resistance determinants related to Tn21, Tn1696, and Tn5053 in enterobacteria from the preantibiotic era.”  Essa A.M.et.al.   12604550
[5] “Four genes, two ends, and a res region are involved in transposition of Tn5053: a paradigm for a novel family of transposons carrying either a mer operon or an integron.”  Kholodii G.Y.et.al.   8594337
[6] “NMR structure determination of a membrane protein with two transmembrane helices in micelles: MerF of the bacterial mercury detoxification system.”  Howell S.C.et.al.   15794657
[7] “Structure determination of a membrane protein with two trans-membrane helices in aligned phospholipid bicelles by solid-state NMR spectroscopy.”  De Angelis A.A.et.al.   16967977
Structure:
1WAZ   2H3O   2LJ2   2M67   2MOZ     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKDPKTLLRV SIIGTTLVAL CCFTPVLVIL LGVVGLSALT GYLDYVLLPA LAIFIGLTIY 
61:	AIQRKRQADA CCTPKFNGVK K