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1.A.72.5.1
The Mercuric ion (Hg2+) uptake transporter, MerE (78aas; 2 TMSs).

Accession Number:Q57069
Protein Name:MerE
Length:78
Molecular Weight:8069.00
Species:Escherichia coli [562]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Early endosome membrane1 / Multi-pass membrane protein2
Substrate Hg2+

Cross database links:

RefSeq: YP_001096342.1    YP_001096403.1    YP_001688204.1    YP_002891177.1   
Entrez Gene ID: 4924667    4924728    5951224    7872410   
Pfam: PF05052   

References (14)

[1] “Mercury resistance determinants related to Tn21, Tn1696, and Tn5053 in enterobacteria from the preantibiotic era.”  Essa A.M.et.al.   12604550
[2] “blaCMY-2-positive IncA/C plasmids from Escherichia coli and Salmonella enterica are a distinct component of a larger lineage of plasmids.”  Call D.R.et.al.   19949054
[3] “International spread and persistence of TEM-24 is caused by the confluence of highly penetrating enterobacteriaceae clones and an IncA/C2 plasmid containing Tn1696::Tn1 and IS5075-Tn21.”  Novais A.et.al.   19995930
[4] “Facile recovery of individual high-molecular-weight, low-copy-number natural plasmids for genomic sequencing.”  Williams L.E.et.al.   16820486
[5] “In117, an unusual In0-like class 1 integron containing CR1 and bla(CTX-M-2) and associated with a Tn21-like element.”  Valverde A.et.al.   16436750
[6] “Transposon Tn21, flagship of the floating genome.”  Liebert C.A.et.al.   10477306
[7] “Tn5060 from the Siberian permafrost is most closely related to the ancestor of Tn21 prior to integron acquisition.”  Kholodii G.et.al.   14553919
[8] “Mercury resistance determinants related to Tn21, Tn1696, and Tn5053 in enterobacteria from the preantibiotic era.”  Essa A.M.et.al.   12604550
[9] “blaCMY-2-positive IncA/C plasmids from Escherichia coli and Salmonella enterica are a distinct component of a larger lineage of plasmids.”  Call D.R.et.al.   19949054
[10] “International spread and persistence of TEM-24 is caused by the confluence of highly penetrating enterobacteriaceae clones and an IncA/C2 plasmid containing Tn1696::Tn1 and IS5075-Tn21.”  Novais A.et.al.   19995930
[11] “Facile recovery of individual high-molecular-weight, low-copy-number natural plasmids for genomic sequencing.”  Williams L.E.et.al.   16820486
[12] “In117, an unusual In0-like class 1 integron containing CR1 and bla(CTX-M-2) and associated with a Tn21-like element.”  Valverde A.et.al.   16436750
[13] “Transposon Tn21, flagship of the floating genome.”  Liebert C.A.et.al.   10477306
[14] “Tn5060 from the Siberian permafrost is most closely related to the ancestor of Tn21 prior to integron acquisition.”  Kholodii G.et.al.   14553919

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNAPDKLPPE TRQPVSGYLW GALAVLTCPC HLPILAAVLA GTTAGAFLGE HWGVAALALT 
61:	GLFVLAVTRL LRAFRGGS