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1.A.74.1.1
Mitsugumin 23 (MG23), also called TM protein 109 (Venturi et al., 2011). MG23 is a Ca2+ channel protein that is regulated by cytoplasmic Zn2+, and dysregulation of this ion channel plays a role in diastolic sarcoplasmic reticulum Ca2+ homeostasis, promoting leakage from the SR (Reilly-O'Donnell et al. 2017).

Accession Number:Q3UBX0
Protein Name:Transmembrane protein 109
Length:243
Molecular Weight:26306.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Nucleus outer membrane1 / Multi-pass membrane protein2
Substrate K+, Ca2+

Cross database links:

Genevestigator: Q3UBX0
eggNOG: roNOG16882
HEGENOM: HBG125768
Entrez Gene ID: 68539   
KEGG: mmu:68539   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005640 C:nuclear outer membrane
GO:0033017 C:sarcoplasmic reticulum membrane

References (2)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGAHSTPLW SRHLLKAVLM VLVALFLVHS ASAQSHREFA SPGQQKKETS ADILTQIGRS 
61:	LKEMLDTWLG PETMHVISET LLQVMWAISS AISVACFALS GIAAQLLSAL GLDGEQLTQG 
121:	LKLSPSQVQT LLLWGAAALV IYWLLSLLLG LVLALLGRIL GGLKLVLFVA GFVALVRSVP 
181:	DPSTRALMLL ALLTLFALLS RLTGSRSSGS HLEAKVRGLE RQIEELRGRQ RRAAKMPRSM 
241:	EEE