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1.A.74.2.2
BRI3 binding protein.  Plays a role in tumorigenesis.  BRI3 is a member of the BRI gene family that includes the familial British and Danish dementia gene BRI2.  BRI3 interacts with the Amyloid Precursor Protein, APP, and serves as an endogenous negative regulator of Abeta production (Matsuda et al. 2009).

Accession Number:Q8WY22
Protein Name:BRI3-binding protein
Length:251
Molecular Weight:27836.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Mitochondrion outer membrane1 / Multi-pass membrane protein2
Substrate K+, Ca2+

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MGARASGGPL ARAGLLLLLL LLLLLGLLAP GAQGARGRGG AEKNSYRRTV NTFSQSVSSL 
61:	FGEDNVRAAQ KFLARLTERF VLGVDMFVET LWKVWTELLD VLGLDVSNLS QYFSPASVSS 
121:	SPARALLLVG VVLLAYWFLS LTLGFTFSVL HVVFGRFFWI VRVVLFSMSC VYILHKYEGE 
181:	PENAVLPLCF VVAVYFMTGP MGFYWRSSPS GPSNPSNPSV EEKLEHLEKQ VRLLNIRLNR 
241:	VLESLDRSKD K