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1.A.76.1.1
Magnesium transporter, MagT1 (Goytain and Quamme, 2005; Schmitz et al., 2007; Zhou and Clapham, 2009)

Accession Number:Q9H0U3
Protein Name:MAGT1
Length:335
Molecular Weight:38037.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Mg2+

Cross database links:

Genevestigator: Q9H0U3
RefSeq: NP_115497.4   
Entrez Gene ID: 84061   
Pfam: PF04756   
OMIM: 300715  gene
300716  phenotype
KEGG: hsa:84061   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008250 C:oligosaccharyltransferase complex
GO:0018279 P:protein amino acid N-linked glycosylation v...

References (9)

[1] “Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties.”  Goytain A.et.al.   15804357
[2] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[5] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[6] “The DNA sequence and comparative analysis of human chromosome 10.”  Deloukas P.et.al.   15164054
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.”  Kelleher D.J.et.al.   12887896
[9] “Oligosaccharyltransferase-subunit mutations in nonsyndromic mental retardation.”  Molinari F.et.al.   18455129

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAARWRFWCV SVTMVVALLI VCDVPSASAQ RKKEMVLSEK VSQLMEWTNK RPVIRMNGDK 
61:	FRRLVKAPPR NYSVIVMFTA LQLHRQCVVC KQADEEFQIL ANSWRYSSAF TNRIFFAMVD 
121:	FDEGSDVFQM LNMNSAPTFI NFPAKGKPKR GDTYELQVRG FSAEQIARWI ADRTDVNIRV 
181:	IRPPNYAGPL MLGLLLAVIG GLVYLRRSNM EFLFNKTGWA FAALCFVLAM TSGQMWNHIR 
241:	GPPYAHKNPH TGHVNYIHGS SQAQFVAETH IVLLFNGGVT LGMVLLCEAA TSDMDIGKRK 
301:	IMCVAGIGLV VLFFSWMLSI FRSKYHGYPY SFLMS