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1.A.76.1.2
Mg2+ transporter; also called Tumor suppressor candidate 3 isoform a, Tusc3a (69% identity with MagT1) (Zhou and Clapham, 2009).

Accession Number:Q13454
Protein Name:Tumor suppressor candidate 3
Length:348
Molecular Weight:39676.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Mg2+

Cross database links:

Genevestigator: Q13454
eggNOG: prNOG17592
HEGENOM: HBG444974
RefSeq: NP_006756.2    NP_839952.1   
Entrez Gene ID: 7991   
Pfam: PF04756    PF00085   
OMIM: 601385  gene
611093  phenotype
KEGG: hsa:7991   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008250 C:oligosaccharyltransferase complex
GO:0045454 P:cell redox homeostasis
GO:0018279 P:protein amino acid N-linked glycosylation v...

References (5)

[1] “Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22.”  Macgrogan D.et.al.   8661104
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.”  Kelleher D.J.et.al.   12887896
[4] “Oligosaccharyltransferase-subunit mutations in nonsyndromic mental retardation.”  Molinari F.et.al.   18455129
[5] “A defect in the TUSC3 gene is associated with autosomal recessive mental retardation.”  Garshasbi M.et.al.   18452889
Structure:
4M8G   4M90   4M91   4M92     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGARGAPSRR RQAGRRLRYL PTGSFPFLLL LLLLCIQLGG GQKKKENLLA EKVEQLMEWS 
61:	SRRSIFRMNG DKFRKFIKAP PRNYSMIVMF TALQPQRQCS VCRQANEEYQ ILANSWRYSS 
121:	AFCNKLFFSM VDYDEGTDVF QQLNMNSAPT FMHFPPKGRP KRADTFDLQR IGFAAEQLAK 
181:	WIADRTDVHI RVFRPPNYSG TIALALLVSL VGGLLYLRRN NLEFIYNKTG WAMVSLCIVF 
241:	AMTSGQMWNH IRGPPYAHKN PHNGQVSYIH GSSQAQFVAE SHIILVLNAA ITMGMVLLNE 
301:	AATSKGDVGK RRIICLVGLG LVVFFFSFLL SIFRSKYHGY PYSDLDFE