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1.A.77.1.1
Inner membrane 40KD Mitochondrial Ca2+ Channel-forming Uniporter, MCU (DUF607; 350 aas; coiled coil domain protein 109 A) (De Stefani et al., 2011; Drago et al., 2011).  It functions with MICU1, and essential component of the system, and the gatekeeper for Ca2+ uptake (Mallilankaraman et al. 2012a; Mallilankaraman et al. 2012b).  Contributes to metabolism-insulin secretion coupling in clonal pancreatic beta-cells (Alam et al. 2012).  MCU-mediated Ca2+ uptake in beta cells is essential to establish a nutrient-induced mitochondrial pH gradient which is critical for sustained ATP synthesis and metabolism-secretion coupling in insulin-releasing cells (Quan et al. 2015).

Accession Number:Q3UMR5
Protein Name:Calcium uniporter protein, mitochondrial
Length:350
Molecular Weight:39682.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: Q3UMR5
eggNOG: roNOG17600
HEGENOM: HBG444105
Entrez Gene ID: 215999   
Pfam: PF04678   
KEGG: mmu:215999   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0051561 P:elevation of mitochondrial calcium ion concentration
GO:0006851 P:mitochondrial calcium ion transport
GO:0035786 P:protein complex oligomerization

References (5)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “Lineage-specific biology revealed by a finished genome assembly of the mouse.”  Church D.M.et.al.   19468303
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.”  Baughman J.M.et.al.   21685886
[5] “A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.”  De Stefani D.et.al.   21685888

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAAAGRSLL LLLCSRGGGG GAGGCGALTA GCFPGLGVSR HRPHQQHRTA HQRPASWQSV 
61:	GAAYCSTVVP SDDVTVVYQN GLPVISVRLP SRRERCQFTL KPISDSVGVF LRQLQEEDRG 
121:	IDRVAIYSPD GVRVAASTGI DLLLLDDFKL VINDLTYHVR PPKRDLLSHE DAATLNDVKT 
181:	LVQQLYTTLC IEQHQLNKER ELVERLEDLK QQLAPLEKVR IEISRKAEKR TTLVLWGGLA 
241:	YMATQFGILA RLTWWEYSWD IMEPVTYFIT YGSAMAMYAY FVMTRQEYVY PEARDRQYLL 
301:	FFHKGAKKSR FDLEKYNQLK DAIAQAEMDL KRLRDPLQVH LPLRQIGEKE