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1.A.8.10.2
Tonoplast intrinsic protein-a (transports water, urea, glycerol and gases (CO2 and NH3)

Accession Number:Q9XG70
Protein Name:TIPa
Length:247
Molecular Weight:25957.00
Species:Nicotiana tabacum (Common tobacco) [4097]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate water, Urea, glycerol, CO2, ammonia

Cross database links:

Pfam: PF00230   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (1)

[1] “Aquaporin Nt-TIPa can account for the high permeability of tobacco cell vacuolar membrane to small neutral solutes.”  Gerbeau P.et.al.   10417709

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAKIAVGSSR EAIQPDCIQA LIVEFICTFL FVFAGVGSAM AANKLNGDPL VSLFFVAMAH 
61:	ALVVAVTISA GFRISGGHLN PAVTLGLCMG GHITVFRSIL YWIDQLLASV AACALLNYLT 
121:	AGLETPVHTL ANGVSYGQGI IMEVILTFSL LFTVYTTIVD PKKGILEGMG PLLTGLVVGA 
181:	NIMAGGPFSG ASMNPARSFG PAFVSGIWTD HWVYWVGPLI GGGLAGFICE NFFIVRTHVP 
241:	LPSDESF