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1.A.8.10.4
Vacuolar (tonoplast) NH3 channel, TIP2;3 (Loque et al., 2005). [Tip2;2 of wheat is also an NH3/H2O channel (Bertl and Kaldenhoff, 2007)].

Accession Number:Q9FGL2
Protein Name:Aquaporin TIP2-3
Length:250
Molecular Weight:25245.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate ammonia, water

Cross database links:

Genevestigator: Q9FGL2
eggNOG: KOG0223
HEGENOM: HBG705794
RefSeq: NP_199556.1   
Entrez Gene ID: 834794   
Pfam: PF00230   
KEGG: ath:AT5G47450   

Gene Ontology

GO:0042807 C:central vacuole
GO:0016021 C:integral to membrane
GO:0009705 C:plant-type vacuole membrane
GO:0051739 F:ammonia transmembrane transporter activity
GO:0015200 F:methylammonium transmembrane transporter ac...
GO:0055085 P:transmembrane transport

References (3)

[1] “From genome to function: the Arabidopsis aquaporins.”  Quigley F.et.al.   11806824
[2] “Tonoplast intrinsic proteins AtTIP2;1 and AtTIP2;3 facilitate NH3 transport into the vacuole.”  Loque D.et.al.   15665250
[3] “Arabidopsis tonoplast proteins TIP1 and TIP2 interact with the cucumber mosaic virus 1a replication protein.”  Kim M.J.et.al.   17030879

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVKIEVGSVG DSFSVSSLKA YLSEFIATLL FVFAGVGSAV AFAKLTSDGA LDPAGLVAIA 
61:	IAHAFALFVG VSIAANISGG HLNPAVTLGL AIGGNITLIT GFFYWIAQCL GSIVACLLLV 
121:	FVTNGKSVPT HGVSAGLGAV EGVVMEIVVT FALVYTVYAT AADPKKGSLG TIAPIAIGFI 
181:	VGANILAAGP FSGGSMNPAR SFGPAVVSGD LSQIWIYWVG PLVGGALAGL IYGDVFIGSY 
241:	EAVETREIRV