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1.A.8.11.3
Plasma membrane aquaporin 1 (Törnroth-Horsefield et al., 2006).  Transports H2O, H2O2 (Dynowski et al., 2008), O2 and CO2 (Zwiazek et al. 2017).  Forms active heterotetramers with PIP2;1 (1.A.8.11.4); down regulated under drought stress (Najafabadi et al., 2008). Gated by H+, Ca2+, Mn2+ and Cd2+ (Verdoucq et al., 2008). The wheat orthologue has been described (Ayadi et al., 2011). 96% identical to PIP1;3.

Accession Number:P61837
Protein Name:PIP1.1 aka PIP1a aka Aquaporin 1
Length:286
Molecular Weight:30689.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate water

Cross database links:

Genevestigator: P61837
eggNOG: KOG0223
HEGENOM: HBG705794
RefSeq: NP_001078323.1    NP_191702.1   
Entrez Gene ID: 825316   
Pfam: PF00230   
KEGG: ath:AT3G61430   

Gene Ontology

GO:0009941 C:chloroplast envelope
GO:0016021 C:integral to membrane
GO:0005739 C:mitochondrion
GO:0005886 C:plasma membrane
GO:0005773 C:vacuole
GO:0015250 F:water channel activity
GO:0009414 P:response to water deprivation
GO:0055085 P:transmembrane transport
GO:0006833 P:water transport

References (5)

[1] “Water channels in the plant plasma membrane cloned by immunoselection from a mammalian expression system.”  Kammerloher W.et.al.   7920711
[2] “Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.”  Salanoubat M.et.al.   11130713
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “From genome to function: the Arabidopsis aquaporins.”  Quigley F.et.al.   11806824
[5] “Methylation of aquaporins in plant plasma membrane.”  Santoni V.et.al.   16839310

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEGKEEDVRV GANKFPERQP IGTSAQSDKD YKEPPPAPFF EPGELSSWSF WRAGIAEFIA 
61:	TFLFLYITVL TVMGVKRSPN MCASVGIQGI AWAFGGMIFA LVYCTAGISG GHINPAVTFG 
121:	LFLARKLSLT RALYYIVMQC LGAICGAGVV KGFQPKQYQA LGGGANTVAH GYTKGSGLGA 
181:	EIIGTFVLVY TVFSATDAKR NARDSHVPIL APLPIGFAVF LVHLATIPIT GTGINPARSL 
241:	GAAIIYNKDH SWDDHWVFWV GPFIGAALAA LYHVVVIRAI PFKSRS