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1.A.8.8.9
Aquaporin 5 (x-ray structure at 2.0 Å resolution (PDB# 3D9S) is available) (Horsefield et al., 2008). Aqp5 is a marker for proliferation and migration of human breast cancer cells (Jung et al., 2011). Plays a role in chronic obstructive pulmonary diseases (COPD) (Zhao et al. 2014).  Its expression is regulated by androgens (Pust et al. 2015). As in humans, the chicken ortholog, Aqp5, is found in the intestine, the jejunum, ileum and colon (Ramírez-Lorca et al. 2006).

Accession Number:P55064
Protein Name:Aquaporin-5
Length:265
Molecular Weight:28292.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate water

Cross database links:

Genevestigator: P55064
eggNOG: prNOG16715
HEGENOM: HBG705794
DIP: DIP-46292N
RefSeq: NP_001642.1   
Entrez Gene ID: 362   
Pfam: PF00230   
OMIM: 600442  gene
KEGG: hsa:362   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0005515 F:protein binding
GO:0015250 F:water channel activity
GO:0015670 P:carbon dioxide transport
GO:0007588 P:excretion
GO:0042476 P:odontogenesis
GO:0030157 P:pancreatic juice secretion
GO:0055085 P:transmembrane transport
GO:0006833 P:water transport

References (2)

[1] “The human aquaporin-5 gene. Molecular characterization and chromosomal localization.”  Lee M.D.et.al.   8621489
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
Structure:
3D9S   5C5X   5DYE     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKEVCSVAF LKAVFAEFLA TLIFVFFGLG SALKWPSALP TILQIALAFG LAIGTLAQAL 
61:	GPVSGGHINP AITLALLVGN QISLLRAFFY VAAQLVGAIA GAGILYGVAP LNARGNLAVN 
121:	ALNNNTTQGQ AMVVELILTF QLALCIFAST DSRRTSPVGS PALSIGLSVT LGHLVGIYFT 
181:	GCSMNPARSF GPAVVMNRFS PAHWVFWVGP IVGAVLAAIL YFYLLFPNSL SLSERVAIIK 
241:	GTYEPDEDWE EQREERKKTM ELTTR