TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.B.12.2.1
Autoexporter of pertactin, Ptt of 910 aas with a C-terminal β-barrel domain which has been crystalized (Zhu et al. 2007).  It is a bacterial adhesin and vaccine target which influences the duration of B. pertussis infections but does not otherwise affect the disease (Vodzak et al. 2016).

Accession Number:P14283
Protein Name:PERT aka Ptt aka PRN aka OMP69A
Length:910
Molecular Weight:93453.00
Species:Bordetella pertussis [520]
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate Pertactin

Cross database links:

HEGENOM: HBG037649
RefSeq: NP_879839.1   
Entrez Gene ID: 2664290   
Pfam: PF03797    PF03212   
BioCyc: BPER257313:BP1054-MONOMER   
KEGG: bpe:BP1054   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0009986 C:cell surface
GO:0005576 C:extracellular region
GO:0042597 C:periplasmic space
GO:0005886 C:plasma membrane
GO:0005515 F:protein binding
GO:0007155 P:cell adhesion
GO:0009405 P:pathogenesis

References (4)

[1] “Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis.”  Charles I.G.et.al.   2542937
[2] “Cloning, nucleotide sequence and heterologous expression of the protective outer-membrane protein P.68 pertactin from Bordetella bronchiseptica.”  Li J.L.et.al.   1527510
[3] “Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.”  Parkhill J.et.al.   12910271
[4] “Structure of Bordetella pertussis virulence factor P.69 pertactin.”  Emsley P.et.al.   8609998
Structure:
1DAB     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNMSLSRIVK AAPLRRTTLA MALGALGAAP AAHADWNNQS IVKTGERQHG IHIQGSDPGG 
61:	VRTASGTTIK VSGRQAQGIL LENPAAELQF RNGSVTSSGQ LSDDGIRRFL GTVTVKAGKL 
121:	VADHATLANV GDTWDDDGIA LYVAGEQAQA SIADSTLQGA GGVQIERGAN VTVQRSAIVD 
181:	GGLHIGALQS LQPEDLPPSR VVLRDTNVTA VPASGAPAAV SVLGASELTL DGGHITGGRA 
241:	AGVAAMQGAV VHLQRATIRR GDAPAGGAVP GGAVPGGAVP GGFGPGGFGP VLDGWYGVDV 
301:	SGSSVELAQS IVEAPELGAA IRVGRGARVT VSGGSLSAPH GNVIETGGAR RFAPQAAPLS 
361:	ITLQAGAHAQ GKALLYRVLP EPVKLTLTGG ADAQGDIVAT ELPSIPGTSI GPLDVALASQ 
421:	ARWTGATRAV DSLSIDNATW VMTDNSNVGA LRLASDGSVD FQQPAEAGRF KVLTVNTLAG 
481:	SGLFRMNVFA DLGLSDKLVV MQDASGQHRL WVRNSGSEPA SANTLLLVQT PLGSAATFTL 
541:	ANKDGKVDIG TYRYRLAANG NGQWSLVGAK APPAPKPAPQ PGPQPPQPPQ PQPEAPAPQP 
601:	PAGRELSAAA NAAVNTGGVG LASTLWYAES NALSKRLGEL RLNPDAGGAW GRGFAQRQQL 
661:	DNRAGRRFDQ KVAGFELGAD HAVAVAGGRW HLGGLAGYTR GDRGFTGDGG GHTDSVHVGG 
721:	YATYIADSGF YLDATLRASR LENDFKVAGS DGYAVKGKYR THGVGASLEA GRRFTHADGW 
781:	FLEPQAELAV FRAGGGAYRA ANGLRVRDEG GSSVLGRLGL EVGKRIELAG GRQVQPYIKA 
841:	SVLQEFDGAG TVHTNGIAHR TELRGTRAEL GLGMAAALGR GHSLYASYEY SKGPKLAMPW 
901:	TFHAGYRYSW