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1.B.22.2.2
The Type IV pilus biogenesis/competence secretin precursor, PilQ (may serve as a pore for (1) pilus export, (2) DNA uptake, (3) heme uptake, (4) antimicrobial uptake (Tønjum et al., 1998); Binds DNA (Assalkhou et al., 2007); Structure known to 12 Å resolution (Collins et al., 2004) The pilus biogenesis factor, PilW (ABX73034) facilitates formation and/or stability of secretin (PilQ) multimers. The 3-D structure of PilW is known (Trindade et al., 2008).

Accession Number:Q9ZHF3
Protein Name:Type IV pilus biogenesis and competence protein pilQ
Length:766
Molecular Weight:82088.00
Species:Neisseria meningitidis [487]
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Peripheral membrane protein2
Substrate Fimbrial subunits

Cross database links:

Pfam: PF00263    PF03958    PF07660   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0008565 F:protein transporter activity
GO:0030420 P:establishment of competence for transformation
GO:0009297 P:pilus assembly
GO:0009306 P:protein secretion

References (1)

[1] “Structure and function of repetitive sequence elements associated with a highly polymorphic domain of the Neisseria meningitidis PilQ protein.”  Toenjum T.et.al.   9701807

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNTKLTKIIS GLFVATAAFQ TASAGNITDI KVSSLPNKQK IVKVSFDKEI VNPTGFVTSS 
61:	PARIALDFEQ TGISMDQQVL EYADPLLSKI SAAQNSSRAR LVLNLNKPGQ YNTEVRGNKV 
121:	WIFINESDDT VSAPARPAVK AAPAAPAKQQ AAAPSTKSAV SVSEPFTPAK QQAAAPFTES 
181:	VVSVSAPFSP AKQQAAASAK QQAAAPAKQQ AAASAKQQAA APAKQQAAAP AKQTNIDFRK 
241:	DGKNAGIIEL AALGFAGQPD ISQQHDHIIV TLKNHTLPTA LQRSLDVADF KTPVQKVTLK 
301:	RLNNDTQLII TTAGNWELVN KSAAPGYFTF QVLPKKQNLE SGGVNNAPKT FTGRKISLDF 
361:	QDVEIRTILQ ILAKESGMNI VASDSVSGKM TLSLKDVPWD QALDLVMQAR NLDMRQQGNI 
421:	VNMAPRRAAC QRQSLLTTGK RHCRSGRAVF PKLPIEIQKC GRIPQHPALD NADTTGNRNT 
481:	LVSGRGSVLI DPATNTLIVT DTRSVIEKFR KLIDELDVPA QQVMIEARIV EAADGFSRDL 
541:	GVKFGATGRK KLKNETSAFG WGVNSGFGGG DKWEAKPKST CRLPCRKQHF AGARDFSGAL 
601:	NLELSASESL SKPKTLANPR VLTQNRKEAK IESGYEIPFT VTSRSGGGSS TNTELKKAVL 
661:	GLTVTPNITP DGQIIMTVKI NKDSPRQCAS GNQTILCIST KNLNTQAMVE NGGTLIVGGI 
721:	YEEDNGNTLT KVPLLATSPL SATSLKHGEK NRPPRTADFQ LPPREL