TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.B.22.4.1
ComE competence protein secretin

Accession Number:P31772
Protein Name:ComE aka HI0435
Length:445
Molecular Weight:49208.00
Species:Haemophilus influenzae [727]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1
Substrate proteins

Cross database links:

HEGENOM: HBG482665
RefSeq: NP_438596.1   
Entrez Gene ID: 950687   
Pfam: PF00263    PF03958   
BioCyc: HINF71421:HI_0435-MONOMER   
KEGG: hin:HI0435   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0008565 F:protein transporter activity
GO:0030420 P:establishment of competence for transformation
GO:0009297 P:pilus assembly
GO:0009306 P:protein secretion

References (3)

[1] “Nucleotide sequence of a cluster of genes involved in the transformation of Haemophilus influenzae Rd.”  Tomb J.-F.et.al.   1916268
[2] “Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.”  Fleischmann R.D.et.al.   7542800
[3] “Sequence and transcriptional regulation of com101A, a locus required for genetic transformation in Haemophilus influenzae.”  Larson T.G.et.al.   1856167

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MKKYFLKCGY FLVCFCLPLI VFANPKTDNE RFFIRLSQAP LAQTLEQLAF QQDVNLVIGD 
61:	ILENKISLKL NNIDMPRLLQ IIAKSKHLTL NKDDGIYYLN GSQSGKGQVA GNLTTNEPHL 
121:	VSHTVKLHFA KASELMKSLT TGSGSLLSPA GSITFDDRSN LLVIQDEPRS VQNIKKLIAE 
181:	MDKPIEQIAI EARIVTITDE SLKELGVRWG IFNPTENARR VAGSLTGNSF ENIADNLNVN 
241:	FATTTTPAGS IALQVAKING RLLDLELSAL ERENNVEIIA SPRLLTTNKK SASIKQGTEI 
301:	PYIVSNTRND TQSVEFREAV LGLEVTPHIS KDNNILLDLL VSQNSPGSRV AYGQNEVVSI 
361:	DKQEINTQVF AKDGETIVLG GVFHDTITKS EDKVPLLGDI PVIKRLFSKE SERHQKRELV 
421:	IFVTPHILKA GETLEALKQK SEGKK