TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.B.22.7.1
Bundle-forming pilus-B (BfpB) secretin (catalyzes export of pilins and EPEC proteins; uptake of vancomycin). (BfpB complex formation requires BfpG, 113 aas; gbBAA84839).  While the N-terminus is periplasmic, the C-terminus is extracelllular. BfpB may form a beta barrel with 16 transmembrane beta strands with a C-terminal segment passing through the center of each monomer (Lieberman et al. 2015).

Accession Number:Q9S142
Protein Name:BfpB
Length:552
Molecular Weight:58372.00
Species:Escherichia coli   [168927]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Lipid-anchor2
Substrate Pilins, proteins, Vancomycin

Cross database links:

RefSeq: NP_053067.1    YP_001965381.1   
Entrez Gene ID: 1238604    6382170   
Pfam: PF00263    PF07655   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0009297 P:pilus assembly
GO:0009306 P:protein secretion

References (3)

[1] “Enteropathogenic Escherichia coli: identification of a gene cluster coding for bundle-forming pilus morphogenesis.”  Sohel I.et.al.   8626330
[2] “Complete DNA sequence and structural analysis of the enteropathogenic Escherichia coli adherence factor plasmid.”  Tobe T.et.al.   10496929
[3] “BfpB, an outer membrane lipoprotein required for the biogenesis of bundle-forming pili in enteropathogenic Escherichia coli.”  Ramer S.W.et.al.   8932312

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MKLGRYSLFL LCPLLASCSG NGFYKDNLGV IDKNILHADT SLLKSKNKEH YKSSDMVSKT 
61:	DSIYIGNSSF QTYHGEPLPG KLEGVHGIIL RSSTPLGFDE VLSMIQDSSG IPIVKHTTKD 
121:	VISGGVSSKS LAATVAEKMN SATGGKSTDQ FDHLLLEVSS EHQLMDVNYQ GALSTFLDKV 
181:	AANYNLYWTY ESGRIAFSNE ETKRFSISIL PGGKYTSKNS ISSDSNSSSG SSGSSGSSSS 
241:	DSGAELKFDS DVDFWKDIEN SIKLILGSDG SYSISTSTSS VIVRTSSANM KKINEYINTL 
301:	NAQLERQVTI DVAIYNVTTT DSSDLAMSLE ALLKHNGGVL GSVSTSNFAA TSGTPSFTGY 
361:	LNGNGDSSNQ VLLNLLAEKG KVSVVTSASV TTMSGQPVPL KVGNDRTYVS EIGTVLSQSS 
421:	TSTTASTSTV TSGFLMNLLP QVADDGNILL QYGVTLSELV GSNNGFDQAT VNGTVIQLPN 
481:	VDSTTFVQSS MLRNGNTLVL AGYEKKRNES VDQGVGTTSF KLLGGALNGS ASRTVTVICI 
541:	TPRIIDLKAS GE