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1.B.25.1.13
Chitoporin, ChiP or YbfM of 468 aas. Takes up chitosugars such as chitobiose.  It also plays a role in carbapenem (imipenem) resistance.  The orthologue in Proteus mirabilis is ImpR, and that in Salmonella species is YbfM. It is subject to regulation by the small RNA, MicM (Tsai et al. 2015).  Loss of OmpC and OmpF results in poor growth, by expression of chiP restores growth (Knopp and Andersson 2015).

Accession Number:P75733
Protein Name:Uncharacterized protein ybfM
Length:468
Molecular Weight:52780.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:1
Substrate Chitooligosaccharides, Carbapenem

Cross database links:

Genevestigator: P75733
EchoBASE: EB3423
EcoGene: EG13659
eggNOG: NOG14525
HEGENOM: HBG624873
Entrez Gene ID: 945296   
Pfam: PF03573   
KEGG: ecj:JW0667    eco:b0681   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015288 F:porin activity
GO:0006030 P:chitin metabolic process

References (3)

[1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRTFSGKRST LALAIAGVTA MSGFMAMPEA RAEGFIDDST LTGGIYYWQR ERDRKDVTDG 
61:	DKYKTNLSHS TWNANLDFQS GYAADMFGLD IAAFTAIEMA ENGDSSHPNE IAFSKSNKAY 
121:	DEDWSGDKSG ISLYKAAAKF KYGPVWARAG YIQPTGQTLL APHWSFMPGT YQGAEAGANF 
181:	DYGDAGALSF SYMWTNEYKA PWHLEMDEFY QNDKTTKVDY LHSFGAKYDF KNNFVLEAAF 
241:	GQAEGYIDQY FAKASYKFDI AGSPLTTSYQ FYGTRDKVDD RSVNDLYDGT AWLQALTFGY 
301:	RAADVVDLRL EGTWVKADGQ QGYFLQRMTP TYASSNGRLD IWWDNRSDFN ANGEKAVFFG 
361:	AMYDLKNWNL PGFAIGASYV YAWDAKPATW QSNPDAYYDK NRTIEESAYS LDAVYTIQDG 
421:	RAKGTMFKLH FTEYDNHSDI PSWGGGYGNI FQDERDVKFM VIAPFTIF