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1.B.25.1.2
OprE1 (OprE; OccK8) porin (anaerobically induced). May participate in chromate resistance (Rivera et al., 2008). The high-resolution X-ray structure and electrophysiology highlight a very narrow pore. However, transport of natural amino acids and antibiotics, among them ceftazidime, has been demonstrated (Samanta et al. 2018). As in general porins, the internal electric field favors the translocation of polar molecules by gainful energy compensation in the central constriction region. The comparatively narrow pore can undergo a substrate-induced expansion to accommodate relatively large-sized substrates (Samanta et al. 2018).

Accession Number:Q51510
Protein Name:OprE1 aka OPRE aka PA0291
Length:460
Molecular Weight:49667.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate Chromate

Cross database links:

HEGENOM: HBG637898
RefSeq: NP_248982.1   
Entrez Gene ID: 879473   
Pfam: PF03573   
BioCyc: PAER208964:PA0291-MONOMER   
KEGG: pae:PA0291   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015288 F:porin activity
GO:0006810 P:transport

References (2)

[1] “Cloning and nucleotide sequence of anaerobically induced porin protein E1 (OprE) of Pseudomonas aeruginosa PAO1.”  Yamano Y.et.al.   8394980
[2] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKSRKINKSR LALAITAGTL GALAQQAVAA GFIEDSKASL TLRNFYINTD NRNGTASPSK 
61:	QEEWGQGFIL NYQSGFTQGT VGFGVDALGL LGVRLDGGGR AGKSGLDRQP GTVFPLESNG 
121:	EPVHDFASLG LTAKAKVSNT EFRYGTLQPK LPVVTYNDGR LLPVTFEGGQ VTSTDLKDFT 
181:	LVAGQLEHSK GRNSTDNRSL SIAGANGSSA SSRDSNKFYY AGGDYKVNKD LTLQYYYGNL 
241:	DDFYKQHFLG LIHNWQIGPG VLKTDLRAFD SSSDGKNGSR SGRADGYVSS GYYGSGVTKG 
301:	EVDNRAFSGL FTYTVSGHSI GAGYQILNGD SDFPFLNRGD GEGSTAYLIT DVQIGKFQRA 
361:	GERTWQVRYG YDFATVGVPG LTFNTIYLSG DKIKTARGDQ SEWERDISLA YVIPDGTFKG 
421:	LGFTWKNASF RSGLPAAGSS NNQRDQDENR LIVSYTLPLL