TCDB is operated by the Saier Lab Bioinformatics Group

1.B.27 The Helicobacter Outer Membrane Porin (Hop) Family


The Hop family consists of 31 outer membrane proteins in Helicobacter pylori. Five such proteins, HopA-HopE have been shown to function as porins both in bacterial outer membranes and in reconstituted planar bilayer membranes. The HopE protein appears to form a β-barrel with 16 transmembrane amphipathic β-strands. It is the smallest of the characterized Hop family members, but it forms the largest channels with a single channel conductance of 1.5 nS in 1M KCl (Bina et al. 2000).

The generalized transport reaction catalyzed by Hop family porins is:

solute (out) solute (periplasm)

References associated with 1.B.27 family:

Bina, J., M. Bains, and R.E. Hancock. (2000). Functional expression in Escherichia coli and membrane topology of porin HopE, a member of a large family of conserved proteins in Helicobacter pylori. J. Bacteriol. 182: 2370-2375. 10762234