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1.B.38.1.1
Large non-selective MSP porin of 574 aas, with short lived large ion conduction (Mathers et al. 1996). Contains  MOSP_N and MOSP_C domains which exists as periplasmic hydrophilic monomers and trimeric porins, respectively. MOSP_C, destined for the OM, follows the canonical BAM pathway, but formation of a stable periplasmic conformer of MOSP_N involves an export-related, folding pathway not present in E. coli (Puthenveetil et al. 2017).

Accession Number:P74914
Protein Name:Msp
Length:574
Molecular Weight:62610.00
Species:Treponema denticola [158]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

Pfam: PF02722    PF02707   

References (1)

[1] “Conservation of msp, the gene encoding the major outer membrane protein of oral Treponema spp.”  Fenno J.C.et.al.   9023187

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKILSILMI LVLVGGVAFA QVEPEVRGSA TLSWGIDFGA GSETDYTKGG ADNHAVATHG 
61:	FYNTNNFQVR LPFFKRQDFA GGSASKEADV YADVSFKATP VATGWTESGK AVSVKAILHF 
121:	YGAYMTVYGK PDFKANKALG WDPINADDGD QGKDWFNPAF TGWGTKIGYK KADLMGLDVG 
181:	LKLGSNGSWH QKASDGKDGK RREKDSKYAF GLDFAMEPVE KYLGVEATIN ATLGKFFNKT 
241:	PLENPGDYGY NAGNVPANIG GKEGKSGMVN FGLAFKSEPI EEMTVKLGFD GVTGLTYTDN 
301:	EGKIQETLGW DAGLSVGYKW VDAALYLCGT GTKYQGYNVA GNDHTKWKNY GANMAAHLGF 
361:	VSDEEAKKGT GFVDGLAFHV TINAYDLLAK RNSEDIPEAT RKANIGALST YDAALTAYLE 
421:	ANPNKTEADF QADPANAAVV NAFKVAKALF KTKYASIPLG LNLGVSYKYD LTDSMWIKPY 
481:	AEFYAETNHY KQHADTYAGD PDKMIDKLYL GMAYELGVKF QPIEKVQVKA SWEHGKLNKD 
541:	TYEGSFNGGE YMIKTPLNHK MHNGTFVLSL KLTY