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1.B.38.1.4
Major outer membrane sheath protein, Msp, of 543 aas.  Msp has a bipartide structure and exists as periplasmic and outer membrane-integrated trimeric conformers (Anand et al. 2013).  The N-terminal domain (residues 77 - 286) does not insert into the membrane, but the C-terminal domain (residues 332 - 543) does to form pores (Anand et al. 2013).  It resembles the surface exposed variable antigen, TprK (Giacani et al. 2012) which plays roles in immune evasion and persistence.

Accession Number:F7IWF6
Protein Name:Major outer sheath protein
Length:543
Molecular Weight:58270.00
Species:Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [243275]
Number of TMSs:1
Substrate small molecules

Cross database links:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKILAILMI LVLVGGVAFA QLTPQVTAKA SVNWGIDFGA GKNAKAQHGF ENLLDAKVVI 
61:	PLYMGTLNSK TEGDVRMNFD LGVNLAYRFY DQLSNSASPH VAWDSDAEFK LWRKTLSDMS 
121:	ASIHFFGGYM NVYGRPDFST NYAQIWSPIR DNGVAWGPET SGDITGFGTK LGYASDDLAG 
181:	TGLKFDAGLK FGSNGSWKAK GTTAQDKFKV VDLKVGDTLI AGATYYKQNG IDAEGKPIFS 
241:	STAAVFAAPP TVGAGEDGKY LVKTASTATG PAANKYAFGL DLSLGYDKWV TLDFGINATF 
301:	DNVKDFGKAG VHEDVAAGSN PDKPYLGMGL KLGSKPVDGL ALTLAMDALM NVGTDSKVAF 
361:	DLRFDASYKW VALGAYFGND LSAYAGKDKN NKAIGDMAAM IAFKSAASGD TNFVEGLAFG 
421:	VDFRLNHLLS AVPTGDKSTL PMGISAWVNY KYALTDSMWV KPYANFWGET NRKSIDASKT 
481:	DKFFGVAYKV GATFSPAEKI EIDTYWSQGK LSWNKYEGTE GMISAPAFDA HNGTFVIGVK 
541:	VIY