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1.B.39 The Bacterial Porin, OmpW (OmpW) Family

OmpW of Salmonella typhimurium has been shown to be required for the efficient efflux of methyl viologen and benzyl viologen (P. Youderian, personal communication). It functions in parallel with OmpD (NmpC in E. coli) which is the major Salmonella porin. OmpW is also the receptor for colicin S4. Homologues are found in many Gram-negative bacterial species including Pseudomonas, Azotobacter, Desulfitobacterium, Burkholderia, Xanthomonas, Rhodobacter, Ralstonia, Delftia and Rickettsia. One homologue is the major outer membrane protein, OprG of Pseudomonas aeruginosa (Gensberg et al., 1999). Another is the outer membrane protein, AlkL, probably involved in alkane transport (van Beilen et al., 1992).  An x-ray structure of OmpW has been presented (Albrecht et al. 2006).

This family belongs to the: Porin Superfamily I.

References associated with 1.B.39 family:

Albrecht, R., K. Zeth, J. Söding, A. Lupas, and D. Linke. (2006). Expression, crystallization and preliminary X-ray crystallographic studies of the outer membrane protein OmpW from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun 62: 415-418. 16582500
Beketskaia, M.S., D.C. Bay, and R.J. Turner. (2014). Outer membrane protein OmpW participates with small multidrug resistance protein member EmrE in quaternary cationic compound efflux. J. Bacteriol. 196: 1908-1914. 24633876
Gensberg, K., A.W. Smith, F.S. Brinkman, and R.E. Hancock. (1999). Identification of oprG, a gene encoding a major outer membrane protein of Pseudomonas aeruginosa. J. Antimicrob. Chemother. 43: 607-608. 10350397
Gil, F., F. Ipinza, J. Fuentes, R. Fumeron, J.M. Villarreal, A. Aspée, G.C. Mora, C.C. Vásquez, and C. Saavedra. (2007). The ompW (porin) gene mediates methyl viologen (paraquat) efflux in Salmonella enterica serovar typhimurium. Res. Microbiol. 158: 529-536. 17618087
Neher, T.M. and D.R. Lueking. (2009). Pseudomonas fluorescens ompW: plasmid localization and requirement for naphthalene uptake. Can. J. Microbiol. 55: 553-563. 19483784
Pilsl, H., D. Smajs, and V. Braun. (1999). Characterization of colicin S4 and its receptor, OmpW, a minor protein of the Escherichia coli outer membrane. J. Bacteriol. 181: 3578-3581. 10348872
Ritter, A., E. Com, A. Bazire, M.D. Goncalves, L. Delage, G.L. Pennec, C. Pineau, C. Dreanno, C. Compère, and A. Dufour. (2012). Proteomic studies highlight outer-membrane proteins related to biofilm development in the marine bacterium Pseudoalteromonas sp. D41. Proteomics. [Epub: Ahead of Print] 22965736
Sullivan, J.T., S.D. Brown, and C.W. Ronson. (2013). The NifA-RpoN regulon of Mesorhizobium loti strain R7A and its symbiotic activation by a novel LacI/GalR-family regulator. PLoS One 8: e53762. 23308282
Touw, D.S., D.R. Patel, and B. van den Berg. (2010). The crystal structure of OprG from Pseudomonas aeruginosa, a potential channel for transport of hydrophobic molecules across the outer membrane. PLoS One 5: e15016. 21124774
van Beilen, J.B., G. Eggink, H. Enequist, R. Bos, and B. Witholt. (1992). DNA sequence determination and functional characterization of the OCT-plasmid-encoded alkJKL genes of Pseudomonas oleovorans. Mol. Microbiol. 6: 3121-3136. 1453953