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1.B.40.2.3
The trimeric AT adhesin, essential for virulence, UpaG (1674aas) (Valle et al., 2008).  The high resolution structure has been solved using the "dictionary" approach (Hartmann et al. 2012).

Accession Number:A8A667
Protein Name:UpaG of E.coli
Length:1674
Molecular Weight:167983.00
Species:Escherichia coli O9:H4 (strain HS) [331112]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate proteins

Cross database links:

eggNOG: COG5295
HEGENOM: HBG467404
RefSeq: YP_001460404.1   
Entrez Gene ID: 5593200   
Pfam: PF05658    PF05662    PF03895   
KEGG: ecx:EcHS_A3814   

Gene Ontology

GO:0019867 C:outer membrane
GO:0009405 P:pathogenesis

References (1)

[1] “The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates.”  Rasko D.A.et.al.   18676672

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNKIFKVIWN PATGNYTVTS ETAKSRGKKS GRSKLLISAL VAGGLLSSFG ALADNYDGQG 
61:	VDYGDGSASD GWVAIGKGAK ANIFLNNAGA STALGYDAIA EGQYSSAIGS KTHAIGGASM 
121:	AFGVSAISEG DRSIALGASS YSFGQYSMAL GRYSKALGRL SIAMGDSSKA DGANAIALGN 
181:	AAKAAGIMSI GLGDNANASQ DYAMALGAES EAAENATAIG NKAHAKGVNS IALGNGSQAL 
241:	ADSAIAIGQG NKANGADAIA LGNGSQSSGL NAIALGKASV VTGDNSLALG SNTNANGINS 
301:	VALGAGSIAD QDDSVSVGSD SLQRKIVNVK NGTIKADSHD AINGSQLYAI SDSVAKRLGG 
361:	GSSVNVDDGT VKAPTYNLKN GNKNNVGDAL TVLDQFTLQW DQNRDKYSAA HGSSTASVIT 
421:	DVADGAVSDS SKDAVNGSQL KATNDDVETN TTNIATNTGN IATNTANIAT NTTNITNLTD 
481:	TVGDLKDDAL LWNGTAFNAA HGTETTSTIT NVKAGTLSDD STDAVNGSQL KDTNDNVATN 
541:	TTNIASNTAN IATNTSNIAD NTANIATNTS NIADNTANIA TNTSNIAGNT ANIATNTTNI 
601:	AANTTSINSL NTSVDALEQD AMLWNGTAFN AAHGTETTST ITNVKAGTLS DDSTDAVNGS 
661:	QLKATNDNVA TNTTNIASNT ANIATNTANI NTLNTSIDTL EQDAILWNGT AYSAAHGTET 
721:	ASTITNVKAG TLSENSTDAV NGAQLNATNA NVATNTTNIA TNTASINTLN TSIDALEQDA 
781:	LLWDGTAFSA AHGANKDASK ITNVLAGTVS SASTDAINGS QLHGLSSSIA TYLGGGATVS 
841:	DSGVFSGPTY NIDGNDYTNV GAALDAINTS LSDSLGDALL WDSTTGAFSA KHGSTASVIT 
901:	NVADGAVSDS SSDAVNGSQL YDVSNSVVDV LGGGAGVNTD GSISAPTYTI ANTDYDNVGD 
961:	ALNALDTTLD DAMLWDATAG ENGAFSASHD GSASKITNVA AGTISDTSTD AVNGAQLHGV 
1021:	SSSVAEALGG GAAVNSDGSI SAPTYTIADT DYTNVGDAMN AIDSTLDNAL LWDATAGENG 
1081:	AFNASHDGKA SVITNVANGQ INETSTDAVN GSQLNATNML IQNIAGDTSE SYITENGEGI 
1141:	NYVRTNDSGL VFEDASATGV GATAVGYNSV ASGDSSVAIG QNSSSTIESG IALGSSSVSN 
1201:	RVILQGSRDT SVTEDGVVIG YNTSDGELLG ALSIGDDGKY RQIINVADGS EAHDAVTVRQ 
1261:	LQNAIGAVAT TPSKYFHANS TEEDSLAVGE DSLAMGAKTI VNGDAGIGIG LNTLVLTDAI 
1321:	NGIAIGSNAS ANHANSIAMG SGSQTTRGAQ TDYTAYNMDA PQNSVGEFSV GSEDGQRQIT 
1381:	NVAAGSADTD AVNVGQLKVT DERVAQNTQS ITNLNNQVTN LDTRVTNIEN GIGDIVTTGS 
1441:	TKYFKINTDG VDANAQGKDS VAIGSGSIAA ADNSVALGTG SVADEENTIS VGSSTNQRRI 
1501:	TNVAAGKNAT DAVNVAQLKS SEAGGVRYDT KADGSIDYSN ITLGGGNGGT TRISNVSAGV 
1561:	NNNDAVNYAQ LKQSVQETKQ YTDQRMVEMD NKLSKTESKL SGGIASAMAM TGLPQAYTPG 
1621:	ASMASIGGGT YNGESAVALG VSMVSANGRW VYKLQGSTNS QGEYSAALGA GIQW