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1.B.45.1.1
Treponema porin, TP0453 of 287 aas. May be involved in ligand transport, altering membrane permeability at acidic pH (4.0 to 5.5) (Luthra et al. 2011). Incubation of the non-lipidated form with lipid vesicles increases their permeability (Hazlett et al. 2005).

Accession Number:O67998
Protein Name:30klp aka TP0453
Length:287
Molecular Weight:32000.00
Species:Treponema pallidum [160]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

HEGENOM: HBG732018
RefSeq: NP_218894.1   
Entrez Gene ID: 2611031   
BioCyc: TPAL243276:TP_0453-MONOMER   
KEGG: tpa:TP0453   

References (1)

[1] “Complete genome sequence of Treponema pallidum, the syphilis spirochete.”  Fraser C.M.et.al.   9665876
Structure:
3K8G   3K8H   3K8I   3K8J     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIRRRYRGCT QGAWIVSVGM LFASCTSGAW KASVDPLGVV GSGADVYLYF PVAGNENLIS 
61:	RIIENHESKA DIKKIVDRTT AVYGAFFARS KEFRLFGSGS YPYAFTNLIF SRSDGWASTK 
121:	TEHGITYYES EHTDVSIPAP HFSCVIFGSS KRERMSKMLS RLVNPDRPQL PPRFEKECTS 
181:	EGTSQTVALY IKNGGHFITK LLNFPQLNLP LGAMELYLTA RRNEYLYTLS LQLGNAKINF 
241:	PIQFLISRVL NAHIHVEGDR LIIEDGTISA ERLASVISSL YSKKGSS