TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
*1.B.55.1.1 | The β-barrel porin with a superhelical domain containing tetratricopeptide repeats, PgaA or YcdS; exports (deacetylated) poly β-1,6-N-acetyl glucosamine (PGA), a biofilm adhesin that may also play a role in immune evasion (Itoh et al., 2008; Cerca and Jefferson 2008). | Bacteria |
Proteobacteria | PgaA of E. coli (P69434) |
*1.B.55.1.2 | PgaA homologue | Bacteria |
Proteobacteria | PgaA homologue of Burkholderia cepacia |
*1.B.55.1.3 | Bacteria |
Proteobacteria | PgaA homologue of Neisseria wadsworthii | |
*1.B.55.2.1 | Putative porin of 604 aas | Bacteria |
Planctomycetes | Porin of Blastopirellula marina |
*1.B.55.2.2 | Uncharacterized protein of 555 aas and 20 predicted beta strands with an N-terminal TMS. | Bacteria |
Nitrospirae | UP of Candidatus Nitroospira defluvii |
*1.B.55.2.3 | TRP-repeat containing protein of 492 aas and 16 predicted beta strands. | Bacteria |
Proteobacteria | Trp repeat protein of Geobacter daltonii |
*1.B.55.3.1 | Cellulose synthase operon, protein C of 1157 aas and up to 18 C-terminal (720 - 1157 aas) β-strands with a single N-terminal α-TMS, BcsC or YhjL (Zogaj et al. 2001). Translocation across the outer membrane occurs through the BcsC porin, which extends into the periplasm via 19 tetra-tricopeptide repeats (TPR). Acheson et al. 2019 presented the crystal structure of a truncated BcsC, encompassing the last TPR repeat and the complete outer membrane channel domain, revealing a 16-stranded, β barrel pore architecture. The pore is blocked by an extracellular gating loop, while the extended C terminus inserts deeply into the channel and positions a conserved Trp residue near its extracellular exit. The channel is lined with hydrophilic and aromatic residues suggesting a mechanism for facilitated cellulose diffusion based on aromatic stacking and hydrogen bonding (Acheson et al. 2019). | Bacteria |
Proteobacteria | BcsC of E. coli |
*1.B.55.3.2 | Uncharacterized protein of 963 aas | Bacteria |
Nitrospirae | UP of Leptospirillum ferriphilum |