TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.B.63.1.1
The CarO slightly cation-slective imipenem-resistance porin of 243 aas (Siroy et al. 2005).  Plays a role in cabapenum resistance (Fonseca et al. 2013) as well as MDR (Yang et al. 2015).  Implicated in the uptake of ornithine and carbapenem antibiotics. Zahn et al. 2015 reported crystal structures of three isoforms of CarO. The structures show a monomeric eight-stranded barrel lacking an open channel. CarO has a substantial extracellular domain resembling a glove that contains all the divergent residues between the different isoforms.

Accession Number:C0L0K3
Protein Name:CarO
Length:246
Molecular Weight:26506.00
Species:Acinetobacter baumannii [470]
Substrate cations, Imipenem, Carbapenem

Cross database links:

Structure:
4fuv     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MKVLRVLVTT TALLAAGAAM ADEAVVHDSY AFDKNQLIPV GARAEVGTTG YGGALLWQAN 
61:	PYVGLALGYN GGDISWSDDV KVNGSTYDLD MDNNNVYLNA EIRPWGASTN RWAQGLYVAA 
121:	GAAYLDNDYD LTRNVDATRS FRVNNQDFIA GADGVKINGQ MSYKNDIAPY LGFGFAPKIN 
181:	KNWGVFGEVG AYYTGNPTVK LVSSGSAVTT GDQSLEEAVN AEARKIANDD KYKWLPVGKV 
241:	GVNFFW