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1.B.8.1.1
Voltage-dependent anion channel (VDAC) porin

Accession Number:P04840
Protein Name:OMP2 aka VDAC aka POR1 aka YNL055C aka N2441 aka YNL2441C
Length:283
Molecular Weight:30428.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Location1 / Topology2 / Orientation3: Mitochondrion outer membrane1
Substrate anions

Cross database links:

Genevestigator: P04840
eggNOG: fuNOG04899
HEGENOM: HBG396026
DIP: DIP-6453N
RefSeq: NP_014343.1   
Entrez Gene ID: 855669   
Pfam: PF01459   
KEGG: sce:YNL055C   

Gene Ontology

GO:0031307 C:integral to mitochondrial outer membrane
GO:0046930 C:pore complex
GO:0005515 F:protein binding
GO:0008308 F:voltage-gated anion channel activity
GO:0006820 P:anion transport
GO:0006915 P:apoptosis
GO:0007005 P:mitochondrion organization
GO:0055085 P:transmembrane transport

References (9)

[1] “Molecular cloning and sequencing of cDNA for yeast porin, an outer mitochondrial membrane protein: a search for targeting signal in the primary structure.”  Mihara K.et.al.   2408884
[2] “Molecular genetics of the VDAC ion channel: structural model and sequence analysis.”  Forte M.A.et.al.   2442148
[3] “The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae.”  Bergez P.et.al.   8533472
[4] “”  Bergez P.et.al.   8904343
[5] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.”  Philippsen P.et.al.   9169873
[6] “Probing the structure of the mitochondrial channel, VDAC, by site-directed mutagenesis: a progress report.”  Blachly-Dyson E.et.al.   2478533
[7] “The role of yeast VDAC genes on the permeability of the mitochondrial outer membrane.”  Lee A.C.et.al.   9435273
[8] “Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.”  Reinders J.et.al.   17761666
[9] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSPPVYSDIS RNINDLLNKD FYHATPAAFD VQTTTANGIK FSLKAKQPVK DGPLSTNVEA 
61:	KLNDKQTGLG LTQGWSNTNN LQTKLEFANL TPGLKNELIT SLTPGVAKSA VLNTTFTQPF 
121:	FTARGAFDLC LKSPTFVGDL TMAHEGIVGG AEFGYDISAG SISRYAMALS YFAKDYSLGA 
181:	TLNNEQITTV DFFQNVNAFL QVGAKATMNC KLPNSNVNIE FATRYLPDAS SQVKAKVSDS 
241:	GIVTLAYKQL LRPGVTLGVG SSFDALKLSE PVHKLGWSLS FDA