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1.B.8.1.3
VDAC porin. Identical to human VDAC (P21798). Mammals possess three VDACs encoded by three genes, but they are all similar in sequence (~60-70% identical) (Messina et al., 2011).  The 3-d structure of the human VDAC is known (PDB ID 2JK4; Bayrhuber et al. 2008).  Reviewed by Shoshan-Barmatz et al. 2015

Accession Number:P45879
Protein Name:POR1 aka VDAC1
Length:283
Molecular Weight:30741.00
Species:Bos taurus (Bovine) [9913]
Location1 / Topology2 / Orientation3: Mitochondrion outer membrane1
Substrate small molecules

Cross database links:

eggNOG: maNOG11150
RefSeq: NP_776910.2   
Entrez Gene ID: 282119   
Pfam: PF01459   
KEGG: bta:282119   

Gene Ontology

GO:0005741 C:mitochondrial outer membrane
GO:0005886 C:plasma membrane
GO:0046930 C:pore complex
GO:0000166 F:nucleotide binding
GO:0008308 F:voltage-gated anion channel activity
GO:0006820 P:anion transport
GO:0006915 P:apoptosis
GO:0055085 P:transmembrane transport

References (2)

[1] “Cloning and in situ localization of a brain-derived porin that constitutes a large-conductance anion channel in astrocytic plasma membranes.”  Dermietzel R.et.al.   7507248
[2] “Location of the dicyclohexylcarbodiimide-reactive glutamate residue in the bovine heart mitochondrial porin.”  De Pinto V.et.al.   7685355
Structure:
2jk4   2k4t   3emn   5jdp     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAVPPTYADL GKSARDVFTK GYGFGLIKLD LKTKSENGLE FTSSGSANTE TTKVTGSLET 
61:	KYRWTEYGLT FTEKWNTDNT LGTEITVEDQ LARGLKLTFD SSFSPNTGKK NAKIKTGYKR 
121:	EHINLGCDVD FDIAGPSIRG ALVLGYEGWL AGYQMNFETA KSRVTQSNFA VGYKTDEFQL 
181:	HTNVNDGTEF GGSIYQKVNK KLETAVNLAW TAGNSNTRFG IAAKYQIDPD ACFSAKVNNS 
241:	SLIGLGYTQT LKPGIKLTLS ALLDGKNVNA GGHKLGLGLE FQA