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1.B.8.1.7
Voltage-independent, cation-selective porin2 (Porin-2 or Por-2) (converted to anion selective by changing Glu-66 and Glu-163 to lysines; Aiello et al., 2004). One of three paralogues (Craigen and Graham, 2008).  Porin 1 is abundantly expressed in both male and female germ cell tissues; Porin 2 is abundant in testis but in small amounts in ovaries. The immuno-histological stain of ovaries shows that Porin 1 is selectively targeted to follicular cells while Porin 2 is present in mitochondria of the epithelial sheath cells of the ovariole (Specchia et al. 2008).

Accession Number:Q9VKP2
Protein Name: Voltage-dependent anion-selective channel protein 2 aka porin2
Length:293
Molecular Weight:31936.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Location1 / Topology2 / Orientation3: Mitochondrion outer membrane1
Substrate cations

Cross database links:

eggNOG: inNOG05269
RefSeq: NP_609462.1   
Entrez Gene ID: 34499   
Pfam: PF01459   
KEGG: dme:Dmel_CG1713   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005741 C:mitochondrial outer membrane
GO:0005261 F:cation channel activity
GO:0015288 F:porin activity
GO:0008308 F:voltage-gated anion channel activity
GO:0006820 P:anion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAKTPTYPD LGKLARDLFK RGYHPGIWQI DCKTLTNSGI EFFTTGFASQ DNSKVTGSLQ 
61:	SKYKIEDQGL TLTERWNTEN WLFGEIMHRD KLAQGLMLAV EAKFQPGSNE ADGKFKMGYA 
121:	QDNFNFLADI GLNSEPILNC SLVVGHKEFL GGVGTEFDVG NTELKGWKVA LGWTNETATL 
181:	HGELKNGDTW LASLFYKASE KIDAGIEVTK GAGGGEAAEG EQQGGDVVVN LGMIYHLEED 
241:	ALVRAKVNNL VELGLGYEQK LRDGITASIS AVLDCNNFKD GNHRFGVGIA LQC