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1.B.8.2.1
19 β-stranded barrel translocase across the outer membrane, Tom40 (Pfam Porin 3 Superfamily).

Accession Number:P23644
Protein Name:Tom40 aka ISP42 aka MOM38 aka YMR203W aka YM8325.04
Length:387
Molecular Weight:42038.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Location1 / Topology2 / Orientation3: Mitochondrion outer membrane1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

Genevestigator: P23644
eggNOG: fuNOG04556
HEGENOM: HBG327874
DIP: DIP-2540N
RefSeq: NP_013930.1   
Entrez Gene ID: 855243   
Pfam: PF01459   
KEGG: sce:YMR203W   

Gene Ontology

GO:0005742 C:mitochondrial outer membrane translocase co...
GO:0046930 C:pore complex
GO:0015450 F:P-P-bond-hydrolysis-driven protein transmem...
GO:0015266 F:protein channel activity
GO:0008308 F:voltage-gated anion channel activity
GO:0006820 P:anion transport
GO:0030150 P:protein import into mitochondrial matrix

References (5)

[1] “A yeast mitochondrial outer membrane protein essential for protein import and cell viability.”  Baker K.P.et.al.   2250717
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.”  Bowman S.et.al.   9169872
[3] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[4] “Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex.”  Dekker P.J.T.et.al.   9774667
[5] “Biogenesis of Tom40, core component of the TOM complex of mitochondria.”  Rapaport D.et.al.   10427088

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSAPTPLAEA SQIPTIPALS PLTAKQSKGN FFSSNPISSF VVDTYKQLHS HRQSLELVNP 
61:	GTVENLNKEV SRDVFLSQYF FTGLRADLNK AFSMNPAFQT SHTFSIGSQA LPKYAFSALF 
121:	ANDNLFAQGN IDNDLSVSGR LNYGWDKKNI SKVNLQISDG QPTMCQLEQD YQASDFSVNV 
181:	KTLNPSFSEK GEFTGVAVAS FLQSVTPQLA LGLETLYSRT DGSAPGDAGV SYLTRYVSKK 
241:	QDWIFSGQLQ ANGALIASLW RKVAQNVEAG IETTLQAGMV PITDPLMGTP IGIQPTVEGS 
301:	TTIGAKYEYR QSVYRGTLDS NGKVACFLER KVLPTLSVLF CGEIDHFKND TKIGCGLQFE 
361:	TAGNQELLML QQGLDADGNP LQALPQL