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1.C.1.1.1
Colicin Ia.  Residues lining the channel have been identified (Kienker et al. 2008).

Accession Number:P06716
Protein Name:CEIA aka CIA
Length:626
Molecular Weight:69429.00
Species:Escherichia coli [562]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Pfam: PF01024    PF11504   
Drugbank: Drugbank Link   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005102 F:receptor binding
GO:0019835 P:cytolysis
GO:0050829 P:defense response to Gram-negative bacterium

References (3)

[1] “DNA and amino acid sequence analysis of structural and immunity genes of colicins Ia and Ib.”  Mankovich J.A.et.al.   3531169
[2] “Nucleotide polymorphism in colicin E1 and Ia plasmids from natural isolates of Escherichia coli.”  Riley M.A.et.al.   7972047
[3] “Crystal structure of colicin Ia.”  Wiener M.et.al.   9009197
Structure:
1CII   2HDI     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSDPVRITNP GAESLGYDSD GHEIMAVDIY VNPPRVDVFH GTPPAWSSFG NKTIWGGNEW 
61:	VDDSPTRSDI EKRDKEITAY KNTLSAQQKE NENKRTEAGK RLSAAIAARE KDENTLKTLR 
121:	AGNADAADIT RQEFRLLQAE LREYGFRTEI AGYDALRLHT ESRMLFADAD SLRISPREAR 
181:	SLIEQAEKRQ KDAQNADKKA ADMLAEYERR KGILDTRLSE LEKNGGAALA VLDAQQARLL 
241:	GQQTRNDRAI SEARNKLSSV TESLNTARNA LTRAEQQLTQ QKNTPDGKTI VSPEKFPGRS 
301:	STNHSIVVSG DPRFAGTIKI TTSAVIDNRA NLNYLLSHSG LDYKRNILND RNPVVTEDVE 
361:	GDKKIYNAEV AEWDKLRQRL LDARNKITSA ESAVNSARNN LSARTNEQKH ANDALNALLK 
421:	EKENIRNQLS GINQKIAEEK RKQDELKATK DAINFTTEFL KSVSEKYGAK AEQLAREMAG 
481:	QAKGKKIRNV EEALKTYEKY RADINKKINA KDRAAIAAAL ESVKLSDISS NLNRFSRGLG 
541:	YAGKFTSLAD WITEFGKAVR TENWRPLFVK TETIIAGNAA TALVALVFSI LTGSALGIIG 
601:	YGLLMAVTGA LIDESLVEKA NKFWGI