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1.C.1.3.1
Colicin A.  The role of the hydrophobic helical hairpin of the pore-forming domain has been elucidated (Bermejo et al. 2013).  Acidic conditions promote membrane insertion (Pulagam and Steinhoff 2013).

Accession Number:P04480
Protein Name:CEA aka CAA
Length:592
Molecular Weight:62993.00
Species:Citrobacter freundii [546]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

Pfam: PF01024   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005102 F:receptor binding
GO:0019835 P:cytolysis
GO:0050829 P:defense response to Gram-negative bacterium

References (3)

[1] “Complete nucleotide sequence of the structural gene for colicin A, a gene translated at non-uniform rate.”  Morlon J.et.al.   6313941
[2] “The complete nucleotide sequence of the colicinogenic plasmid ColA. High extent of homology with ColE1.”  Morlon J.et.al.   2832701
[3] “Nucleotide sequence of promoter, operator and amino-terminal region of caa, the structural gene of colicin A.”  Morlon J.et.al.   6641715
Structure:
3IAX   3QDR     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MPGFNYGGKG DGTGWSSERG SGPEPGGGSH GNSGGHDRGD SSNVGNESVT VMKPGDSYNT 
61:	PWGKVIINAA GQPTMNGTVM TADNSSMVPY GRGFTRVLNS LVNNPVSPAG QNGGKSPVQT 
121:	AVENYLMVQS GNLPPGYWLS NGKVMTEVRE ERTSGGGGKN GNERTWTVKV PREVPQLTAS 
181:	YNEGMRIRQE AADRARAEAN ARALAEEEAR AIASGKSKAE FDAGKRVEAA QAAINTAQLN 
241:	VNNLSGAVSA ANQVITQKQA EMTPLKNELA AANQRVQETL KFINDPIRSR IHFNMRSGLI 
301:	RAQHNVDTKQ NEINAAVANR DALNSQLSQA NNILQNARNE KSAADAALSA ATAQRLQAEA 
361:	ALRAAAEAAE KARQRQAEEA ERQRQAMEVA EKAKDERELL EKTSELIAGM GDKIGEHLGD 
421:	KYKAIAKDIA DNIKNFQGKT IRSFDDAMAS LNKITANPAM KINKADRDAL VNAWKHVDAQ 
481:	DMANKLGNLS KAFKVADVVM KVEKVREKSI EGYETGNWGP LMLEVESWVL SGIASSVALG 
541:	IFSATLGAYA LSLGVPAIAV GIAGILLAAV VGALIDDKFA DALNNEIIRP AH