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1.C.1.3.6
Colicin-like pore-forming domain protein, PmnH, of 462 aas and 2 C-terminal TMSs.  This protein has a dual-toxin architecture, having both an N-terminal colicin M-like domain, potentially interfering with peptidoglycan synthesis, and a colicin N-type domain, a pore-forming module distinct from the colicin Ia-type domain in Pseudomonas aeruginosa pyocin S5 (Ghequire et al. 2017).  Enhanced killing activity of PmnH under iron-limited growth conditions is due to parasitism of the ferrichrome-type transporter for entry into target cells, a strategy shown here to be used as well by monodomain colicin M-like bacteriocins from pseudomonads (Ghequire et al. 2017).

Accession Number:I4L7C8
Protein Name:Colicin pore forming domain protein
Length:462
Molecular Weight:48524.00
Species:Pseudomonas synxantha BG33R [96901]
Number of TMSs:2
Substrate small molecules

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTIVLPPIVV TATEPGYPAN PGGLPFPAPN PAVVFQGQML ERFAYYRQGL WREMLIKIAN 
61:	EQVTWGMTGG PAPGIVHDLQ SVPFADSYLY FNPGLTSGHG LNYAQQYFQS GGVTSSPGLS 
121:	GGDLTPVAAV GHFLYGKGTP TETSINLFGL NSPSISSAVF NDVLASAPIG TSPISIGNIP 
181:	FTPDATSWQL ATWIDNLSLT LQGTLNKGQD GSYQFNGSVS AANHTYDSMP AGFKAAIGEA 
241:	AANTLQSVFD AHGAMPFEVV IKGETAVTVT KELTPDEKAA YTDAVSFVST ANEQMLQKYG 
301:	ANLSKVAQDM QAEIAGKKVR SYAEAMATFE KISANPAMKL NALDTQAVVD ALNALDKASF 
361:	ADNITRLGKA FGVVGKVVQA EAIREKTVSG FQTGDWKPLM LELEAMAVGT GAGILLATSM 
421:	AFFFPVFASA AAGVVVVALM MAATAAYFDA AKVDEINNLI LN