TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.C.100.1.1
Thermostable direct hemolysin or Kanagawa haemolysin, TDH, Tdh2, trh of 189 aas. It exhibits monovalent cation selectivity in the order: Cs+ > Li+ > K+ > Rb+ > Na+, confirming that TDH is the important leak-inducing agent (Huntley and Hall 1994). The crystal structure is known (3A57_A); Ohnishi et al., 2011).

Accession Number:B3IW71
Protein Name:Thermostable direct hemolysin
Length:189
Molecular Weight:21587.00
Species:Vibrio parahaemolyticus [670]
Number of TMSs:1
Substrate small molecules

Cross database links:

Pfam: PF03347   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019836 P:hemolysis by symbiont of host erythrocytes

References (1)

[1] “Detection of a functional insertion sequence responsible for deletion of the thermostable direct hemolysin gene (tdh) in Vibrio parahaemolyticus.”  Kamruzzaman M.et.al.   18598741

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MKYRYFAKKS FLFISMLAAF KTFAFELPSV PFPAPGSDEI LFVVRDTTFN TNAPVNVKVS 
61:	DFWTNRNVKR KPYKDVYGQS VFTTSGTKWL TSYMTVNIND KDYTMAAVSG YKHGHSAVFV 
121:	KSDQVQLQHS YNSVANFVGE DEDSIPSKMY LDETPEYFVN VEAYESGNGN ILVMCISNKE 
181:	SFFECKHQK