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1.C.101.1.1
The HIV-1 TAT peptide derives from the 101aa Tat protein (facilitates transport of drugs and macromolecules across membranes) (Herce and Garcia, 2007). TAT peptides can traverse cell membranes and generate pores in artificial membranes (Ciobanasu et al., 2010).  Anionic lipids accelerate peptide permeation. Cholesterol hinders transmembrane pore formation and thus modulates solute permeability (Hu and Patel 2016).

Accession Number:Q8UMQ1
Protein Name:Tat protein
Length:101
Molecular Weight:11490.00
Species:Human immunodeficiency virus 1 [11676]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Host nucleus1
Substrate peptides

Cross database links:

Pfam: PF00539   

Gene Ontology

GO:0042025 C:host cell nucleus
GO:0005730 C:nucleolus
GO:0003723 F:RNA binding
GO:0003700 F:transcription factor activity
GO:0044419 P:interspecies interaction between organisms
GO:0006355 P:regulation of transcription, DNA-dependent
GO:0006350 P:transcription
GO:0044196 C:host cell nucleolus
GO:0003700 F:sequence-specific DNA binding transcription factor activity

References (2)

[1] “Molecular characterization of a complex, recombinant human immunodeficiency virus type 1 (HIV-1) isolate (A/G/J/K/?): evidence to support the existence of a novel HIV-1 subtype.”  Paraskevis D.et.al.   11562543
[2] “Molecular characterization of a complex, recombinant human immunodeficiency virus type 1 (HIV-1) isolate (A/G/J/K/?): evidence to support the existence of a novel HIV-1 subtype.”  Paraskevis D.et.al.   11562543

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDPVDPNIEP WNQPGSQPKT ACTNCYCKKC CFHCQVCFIR KGLGISYGRK KRRQRRAAPH 
61:	DNKNHQDLIP KQSLSQARGD STGPKESKKK VESKTKTDPF D