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The anion-selective, small, pore-forming, multistate, persister-promoting toxin, TisB (Gurnev et al., 2012; Steinbrecher et al., 2012). Forms a transmembrane amphipathic α-helix with all charged and hydrophilic residues on one side of the helix. TisB is activated in response to DNA damage by the SOS response and promotes persister formation in a manner similar to HokB (TC# 1.E.53.1.3; Harms et al. 2016).

Accession Number:A5A627
Protein Name:Small toxic protein TisB
Molecular Weight:3222.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Single-pass membrane protein2
Substrate inorganic anions, small molecules

Cross database links:

Genevestigator: A5A627
EcoGene: EG14402
Entrez Gene ID: 5061527   
KEGG: eco:b4618   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane

References (6)

[1] “The complete genome sequence of Escherichia coli K-12.”  Blattner   9278503
[2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi   16738553
[3] “The small RNA IstR inhibits synthesis of an SOS-induced toxic peptide.”  Vogel   15620655
[4] “An antisense RNA inhibits translation by competing with standby ribosomes.”  Darfeuille   17499044
[5] “A small SOS-induced toxin is targeted against the inner membrane in Escherichia coli.”  Unoson   18761622
[6] “Repression of small toxic protein synthesis by the Sib and OhsC small RNAs.”  Fozo   18710431

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FASTA formatted sequence