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1.C.107.1.1
Insecticidal toxin complex (TC) component, TcaA (1095 aas) (may mediate toxin-C internalization)(Landsberg et al., 2011).  The TcdA1 prepore assembles as a pentamer forming an α-helical, vuvuzela-shaped channel less than 1.5 nanometres in diameter surrounded by a large outer shell (Gatsogiannis et al. 2013). Membrane insertion is triggered not only at low pH as expected, but also at high pH, explaining Tc action directly through the midgut of insects. Comparisons with structures of the TcdA1 pore inserted into a membrane and in complex with TcdB2 and TccC3 reveal large conformational changes during membrane insertion, suggesting a novel syringe-like mechanism of protein translocation (Gatsogiannis et al. 2013).  P. luminescens is a nematode symbiont and an insect pathogen.  The toxin, TcC, of the tripartite toxin complex, is an ADP ribosyl transferase causing actin clustering, defects in phagocytosis and cell dealth.

Accession Number:Q66PW7
Protein Name:TcaA
Length:1095
Molecular Weight:119513.00
Species:Photorhabdus luminescens subsp. luminescens [171439]
Substrate toxin

Cross database links:

Pfam: PF03538   

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FASTA formatted sequence
1:	MVTVMQNKVS FLSGTSEQPL LDAGYQNVFD IASISRAAFV QSVPTLPVKE AHTVYRQARQ 
61:	RAENLKSLYR AWQLRQEPVI KGLTKLNAQA NVSVLQDALV ENIGGDGDFS DLMNRASQYA 
121:	DAASIQSLFS PGRYATALYK VAKDLHKSDS SLHIDNRRAD LKDLILNETM MNKEVTSLDI 
181:	LLDILQKGSK DITELSSAFF PMTLPYDDHL SQIDSALSAQ ARTLNGVWNT LTDTTAQAVS 
241:	EQAGNTNTLK LFAAQNDNQD TFFAGNTFYF KAVGFGEQPM VYPSQYTSGS GIVGAQLIAG 
301:	NPDQAAAAIV APLQLTWSMA KQCYYLGAPD GTTMGDGNVL TGCFLRGNSP TNPDQNGIFA 
361:	QVANKSGSTQ PISGFHLPVT LERSEDKDKY YLKTEQGYIA VGSSGQSNWK NALVINGTKD 
421:	NGLLLTFCSD SSGTPTNPDD VIPPAINDIP SPPARETLSL TPVSYQLMTN LAPTEDDITH 
481:	HYGLGGSSLR DATSSASALT TALNSIETFC EKTRINFNQL MDLTAQQSYS QSSVDAKAAS 
541:	RYVRFGETAA TRVNVYGAAY LNSTLAAAAD GQYLWIQTDG KSLNFTDDTV VALAGRAEKL 
601:	VRLSSQTGLS FEELDWLIVN ASRSVPDHHD KIVLDKPVLE ALAEYVSLKQ RYGLDANTFV 
661:	TFISAVNPYT PDQTPSFYET TFRSADGNHV IALGTAVKYA ENEQDELSTI CCKALGVTSD 
721:	EFFRIGRYCF GNAGSFTLDE YTASQLYRFG AIPRLFGLTF AQAEILWRLM EGGKDILLQQ 
781:	LGQAKSLQPL AILRRTEQVL DWMSSVNLSL TYLQGMVSTQ WSGTATAEMF NFLENVCDSV 
841:	NSQTAAKETM DSALQQKVLR ALSAGFGIKS NVMGIVTFWL EKITASSGNP FTLANYWHDI 
901:	QTLFSHNNAT LDNLQTDTFL VIATQQLSQL VLIVKWLSLT EQDLQLLTTY PERLLNGITH 
961:	VPAPNPELLL TLSRFKQWQT QVTVSRDEAM RCFDQLNAEG MTADSAASLI ATLHEMDKGT 
1021:	VAQVNTLLSG ENNWPKSFTS LWQLLTWLRV GQSLNVGSTT LGNLLAMMQA DPAAESSALL 
1081:	ASVAQNLSAA ISNRQ