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1.C.11.1.1
Leukotoxin, HlaA

Accession Number:P55117
Protein Name:LKAA aka HlaA aka LKTA
Length:955
Molecular Weight:102128.00
Species:Pasteurella haemolytica [47735]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Secreted1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

Pfam: PF00353    PF02382    PF08339   

Gene Ontology

GO:0020002 C:host cell plasma membrane
GO:0016021 C:integral to membrane
GO:0005509 F:calcium ion binding
GO:0019835 P:cytolysis
GO:0019836 P:hemolysis by symbiont of host erythrocytes
GO:0009405 P:pathogenesis

References (3)

[1] “Molecular analysis of the leukotoxin determinants from Pasteurella haemolytica serotypes 1 to 16.”  Burrows L.L.et.al.   8225575
[2] “Characterization of epitopes involved in the neutralization of Pasteurella haemolytica serotype A1 leukotoxin.”  Lainson F.A.et.al.   8828217
[3] “Sequence diversity and molecular evolution of the leukotoxin (lktA) gene in bovine and ovine strains of Mannheimia (Pasteurella) haemolytica.”  Davies R.L.et.al.   11157953

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGTKLTLSTL SNGIRSTLTA TRGGLNRAGQ SLTQAGQTLK NGAKKIILYI PKDYKYDSGS 
61:	GNGLQDLVKA AEELGIEVQK EEGNDIAKAQ TSLGTIQNVL GLTERGIVLS APQLDKLLQK 
121:	NKVGQALGSS ESIAQNFSQA KTVLSGVQSI LGSVLAGMDL DEALQNESDQ LTLAKAGLEL 
181:	TNSLIENIAN SVQTLDAFSE QISQFGSKLQ NVKGLGALGD KLKNIGGLDK AGLGLDVISG 
241:	LLSGATAALV LADKDASTAK KVGAGFELAN QVVGNITKAV SSYILAQRVA AGLSSTGPVA 
301:	ALIASTVALA ISPLSFAGIA DKFDRAKSLE NYAERFKKLG YEGDSLLAEY QHGTGTIDAS 
361:	VTAINTALAA IAGGVSAAAA GSVVASPIAL LVSGITGVIS TILQYSKQAM FEHVANKIHN 
421:	KIVEWEKNNG GKNYFENGYD ARYLANLQDN MKFLLNLNKE LQAERVIAIT QQQWDSNIGD 
481:	LAGISRLGEK VLSGKAYVDA FEEGQHLKAD KLVQLDSAKG IIDVSNTGEA KTQHILFRTP 
541:	LLTPGTEKRE RVQTGKYEYI TKLHINRVDS WQIKDGAASS TFDLTNVVQR IGVELDHAEN 
601:	VIKTKETKIV ATLGDGDDNV FVGSGTTEID GGEGYDRVHY SRGNYGALTI DATKETEQGS 
661:	YTVNRFVESG KALHEVTSTH TALVGNREEK IEYRHSNNQH HAGYYTKDTL KAVEEIIGTS 
721:	HNDIFKGSKF NDAFNGGDGV DTIDGNDGND RLFGGKGDDI IDGGNGDDFI DGGKGNDLLH 
781:	GGKGDDIFVH RQGDGNDSIT ESEGNDKLSF SDSNLKDLTF EKVNHHLVIT NTKQEKVTIQ 
841:	NWFREAEFAK TIRNYVATRD DKIEEIIGQN GERITSKQVD ELIEKGKGKI DKSDLSQVVD 
901:	NYQLLKYSRD ASNSLDKLIS SASAFTSSND SRNVLASPTS MLDPSLSSIQ FARAA