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1.C.11.1.2
RTX-toxin IIA; haemolysin IIA; cytolysin IIA, ClyIIA

Accession Number:P15377
Protein Name:RT2A aka ClyIIA aka APXIIA aka HLYIIA aka APPA aka CYTC
Length:956
Molecular Weight:102532.00
Species:Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae) [715]
Location1 / Topology2 / Orientation3: Secreted1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

Pfam: PF00353    PF02382    PF08339   

Gene Ontology

GO:0020002 C:host cell plasma membrane
GO:0016021 C:integral to membrane
GO:0005509 F:calcium ion binding
GO:0019835 P:cytolysis
GO:0019836 P:hemolysis by symbiont of host erythrocytes
GO:0009405 P:pathogenesis

References (2)

[1] “Cloning and characterization of a hemolysin gene from Actinobacillus (Haemophilus) pleuropneumoniae.”  Chang Y.-F.et.al.   2693022
[2] “Cytolysins of Actinobacillus pleuropneumoniae serotype 9.”  Smits M.A.et.al.   1937809

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSKITLSSLK SSLQQGLKNG KNKLNQAGTT LKNGLTQTGH SLQNGAKKLI LYIPQGYDSG 
61:	QGNGVQDLVK AANDLGIEVW REERSNLDIA KTSFDTTQKI LGFTDRGIVL FAPQLDNLLK 
121:	KNPKIGNTLG SASSISQNIG KANTVLGGIQ SILGSVLSGV NLNELLQNKD PNQLELAKAG 
181:	LELTNELVGN IASSVQTVDA FAEQISKLGS HLQNVKGLGG LSNKLQNLPD LGKASLGLDI 
241:	ISGLLSGASA GLILADKEAS TEKKAAAGVE FANQIIGNVT KAVSSYILAQ RVASGLSSTG 
301:	PVAALIASTV ALAVSPLSFL NVADKFKQAD LIKSYSERFQ KLGYDGDRLL ADFHRETGTI 
361:	DASVTTINTA LAAISGGVGA ASAGSLVGAP VALLVAGVTG LITTILEYSK QAMFEHVANK 
421:	VHDRIVEWEK KHNKNYFEQG YDSRHLADLQ DNMKFLINLN KELQAERVVA ITQQRWDNQI 
481:	GDLAAISRRT DKISSGKAYV DAFEEGQHQS YDSSVQLDNK NGIINISNTN RKTQSVLFRT 
541:	PLLTPGEENR ERIQEGKNSY ITKLHIQRVD SWTVTDGDAS SSVDFTNVVQ RIAVKFDDAG 
601:	NIIESKDTKI IANLGAGNDN VFVGSSTTVI DGGDGHDRVH YSRGEYGALV IDATAETEKG 
661:	SYSVKRYVGD SKALHETIAT HQTNVGNREE KIEYRREDDR FHTGYTVTDS LKSVEEIIGS 
721:	QFNDIFKGSQ FDDVFHGGNG VDTIDGNDGD DHLFGGAGDD VIDGGNGNNF LVGGTGNDII 
781:	SGGKDNDIYV HKTGDGNDSI TDSGGQDKLA FSDVNLKDLT FKKVDSSLEI INQKGEKVRI 
841:	GNWFLEDDLA STVANYKATN DRKIEEIIGK GGERITSEQV DKLIKEGNNQ ISAEALSKVV 
901:	NDYNTSKDRQ NVSNSLAKLI SSVGSFTSSS DFRNNLGTYV PSSIDVSNNI QLARAA