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1.C.11.1.7
Leukotoxin A, LtxA pore-forming toxin of 1055 aas, exhibiting β-hemolytic activity.  Plays a role in immune evasion by lysing human lymphocytes and monocytes. It binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, resulting in large LtxA-LFA-1 clusters in lipid rafts (Balashova et al. 2006; Brown et al. 2013).  Blocking P2X receptors protects monocytes from LtxA (Fagerberg et al. 2016).

Accession Number:P16462
Protein Name:Leukotoxin
Length:1055
Molecular Weight:113854.00
Species:Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) [714]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Peripheral membrane protein2 / Extracellular side3
Substrate small molecules

Cross database links:

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MATTTLPNTK QQAAQFANSV ADRAKENIDA AKEQLQKALD KLGKTGKKLT LYIPKNYKKG 
61:	NGLTALIKAA QKLGIEVYHE GKDGPALTNG ILNTGKKLLG LTERGLTLFA PELDKWIQGN 
121:	KHLSNSVGST GNLTKAIDKV QSVLGTLQAF LNTAFSGMDL DALIKARQNG KNVTDVQLAK 
181:	ASLNLINELI GTISSITNNV DTFSKQLNKL GEALGQVKHF GSFGDKLKNL PKLGNLGKGL 
241:	GALSGVLSAI SAALLLANKD ADTATKAAAA AELTNKVLGN IGKAITQYLI AQRAAAGLST 
301:	TGPVAGLIAS VVSLAISPLS FLGIAKQFDR ARMLEEYSKR FKKFGYNGDS LLGQFYKNTG 
361:	IADAAITTIN TVLSAIAAGV GAASAGSLVG APIGLLVSAI TSLISGILDA SKQAVFEHIA 
421:	NQLADKIKAW ENKYGKNYFE NGYDARHSAF LEDSLKLFNE LREKYKTENI LSITQQGWDQ 
481:	RIGELAGITR NGDRIQSGKA YVDYLKKGEE LAKHSDKFTK QILDPIKGNI DLSGIKGSTT 
541:	LTFLNPLLTA GKEERKTRQS GKYEFITELK VKGRTDWKVK GVPNSNGVYD FSNLIQHAVT 
601:	RDNKVLEARL IANLGAKDDY VFVGSGSTIV NAGDGYDVVD YSKGRTGALT IDGRNATKAG 
661:	QYKVERDLSG TQVLQETVSK QETKRGKVTD LLEYRNYKLD YYYTNKGFKA HDELNSVEEI 
721:	IGSTLRDKFY GSKFNDVFHG HDGDDLIYGY DGDDRLYGDN GNDEIHGGQG NDKLYGGAGN 
781:	DRLFGEYGNN YLDGGEGDDH LEGGNGSDIL RGGSGNDKLF GNQGDDLLDG GEGDDQLAGG 
841:	EGNDIYVYRK EYGHHTITEH SGDKDKLSLA NINLKDVSFE RNGNDLLLKT NNRTAVTFKG 
901:	WFSKPNSSAG LDEYQRKLLE YAPEKDRARL KRQFELQRGK VDKSLNNKVE EIIGKDGERI 
961:	TSQDIDNLFD KSGNKKTISP QELAGLIKNK GKSSSLMSSS RSSSMLTQKS GLSNDISRII 
1021:	SATSGFGSSG KALSASPLQT NNNFNSYANS LATTA