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1.C.111.1.12
Dendritic cell natural killer lectin group receptor 1, DNGR-1, of 238 aas and 1 N-terminal TMS. It is also called C-type lectin domain family 9 member A (Cle9a). It functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells (Sancho et al. 2009). It recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged. It mediates the cross-presentation of dead-cell associated antigens in a Syk-dependent manner (Sancho et al. 2009; ). DNGR-1 is a receptor expressed by certain dendritic cell (DC) subsets and by DC precursors in the mouse. It possesses a C-type lectin-like domain (CTLD) followed by a poorly characterized neck region coupled to a transmembrane region and short intracellular tail. The CTLD of DNGR-1 binds F-actin exposed by dead cell corpses and causes the receptor to signal and potentiate cross-presentation of dead cell-associated antigens by DCs.The neck region of DNGR-1 is an integral receptor component that senses receptor progression through the endocytic pathway and has evolved to maximize extraction of antigens from cell corpses (HanĨ et al. 2016).

Accession Number:Q8BRU4
Protein Name:C-type lectin domain family 9 member A
Length:238
Molecular Weight:27014.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type II membrane protein2
Substrate small molecules

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MHAEEIYTSL QWDIPTSEAS QKCQSPSKCS GAWCVVTMIS CVVCMGLLAT SIFLGIKFFQ 
61:	VSSLVLEQQE RLIQQDTALV NLTQWQRKYT LEYCQALLQR SLHSGSDCSP CPHNWIQNGK 
121:	SCYYVFERWE MWNISKKSCL KEGASLFQID SKEEMEFISS IGKLKGGNKY WVGVFQDGIS 
181:	GSWFWEDGSS PLSDLLPAER QRSAGQICGY LKDSTLISDK CDSWKYFICE KKAFGSCI