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1.C.111.1.13
NKG2-D type II protein of 216 aas and 1 central TMS. Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity (Zafirova et al. 2011). It stimulates perforin-mediated elimination of ligand-expressing tumor cells; signaling involves calcium influx, culminating in the expression of TNF-alpha (Zuo et al. 2017).

Accession Number:P26718
Protein Name:NKG2-D type II integral membrane protein
Length:216
Molecular Weight:25274.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass type II membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGWIRGRRSR HSWEMSEFHN YNLDLKKSDF STRWQKQRCP VVKSKCRENA SPFFFCCFIA 
61:	VAMGIRFIIM VAIWSAVFLN SLFNQEVQIP LTESYCGPCP KNWICYKNNC YQFFDESKNW 
121:	YESQASCMSQ NASLLKVYSK EDQDLLKLVK SYHWMGLVHI PTNGSWQWED GSILSPNLLT 
181:	IIEMQKGDCA LYASSFKGYI ENCSTPNTYI CMQRTV