TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.C.111.1.2
Regenerating islet-derived protein 3α, RegIIIα or Reg3A.  Also called Proliferation-induced Protein 34, PAP or HIP of 157 aas.  It is a C-type intestinal lectin and forms hexameric pores in Gram-positive bacterial membranes.  The 3-d x-ray structure is known (Mukherjee et al. 2014).  Lipopolysaccharides inhibit pore formation, and hence, Gram-negative bacteria are usually not susceptible to its killing action (Mukherjee et al. 2014). 

Accession Number:Q06141
Protein Name:Regenerating islet-derived protein 3-alpha
Length:175
Molecular Weight:19395.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Structure:
1UV0   2GO0   4MTH     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MLPPMALPSV SWMLLSCLML LSQVQGEEPQ RELPSARIRC PKGSKAYGSH CYALFLSPKS 
61:	WTDADLACQK RPSGNLVSVL SGAEGSFVSS LVKSIGNSYS YVWIGLHDPT QGTEPNGEGW 
121:	EWSSSDVMNY FAWERNPSTI SSPGHCASLS RSTAFLRWKD YNCNVRLPYV CKFTD