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1.C.113.2.1
The monocyte to macrophage differentiation protein (MMDP)

Accession Number:Q15546
Protein Name:MMDP aka MMD
Length:238
Molecular Weight:27667.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Late endosome membrane1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

Genevestigator: Q15546
eggNOG: prNOG17953
HEGENOM: HBG717325
RefSeq: NP_036461.2   
Entrez Gene ID: 23531   
Pfam: PF03006   
OMIM: 604467  gene
KEGG: hsa:23531   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0031902 C:late endosome membrane
GO:0005765 C:lysosomal membrane
GO:0005624 C:membrane fraction
GO:0004872 F:receptor activity
GO:0019835 P:cytolysis

References (4)

[1] “Molecular cloning of a novel macrophage maturation-associated transcript encoding a protein with several potential transmembrane domains.”  Rehli M.et.al.   7503749
[2] “PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif.”  Tang Y.T.et.al.   16044242
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRFKNRFQRF MNHRAPANGR YKPTCYEHAA NCYTHAFLIV PAIVGSALLH RLSDDCWEKI 
61:	TAWIYGMGLC ALFIVSTVFH IVSWKKSHLR TVEHCFHMCD RMVIYFFIAA SYAPWLNLRE 
121:	LGPLASHMRW FIWLMAAGGT IYVFLYHEKY KVVELFFYLT MGFSPALVVT SMNNTDGLQE 
181:	LACGGLIYCL GVVFFKSDGI IPFAHAIWHL FVATAAAVHY YAIWKYLYRS PTDFMRHL