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1.C.12.1.2
Alveolysin

Accession Number:P23564
Protein Name:TACY aka ALV
Length:501
Molecular Weight:55268.00
Species:Paenibacillus alvei (Bacillus alvei) [44250]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules, large molecules

Cross database links:

Pfam: PF01289   

Gene Ontology

GO:0015485 F:cholesterol binding
GO:0019835 P:cytolysis
GO:0019836 P:hemolysis by symbiont of host erythrocytes
GO:0009405 P:pathogenesis

References (1)

[1] “Alveolysin, the thiol-activated toxin of Bacillus alvei, is homologous to listeriolysin O, perfringolysin O, pneumolysin, and streptolysin O and contains a single cysteine.”  Geoffroy C.et.al.   2254290

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MKKKSNHLKG RKVLVSLLVS LQVFAFASIS SAAPTEPNDI DMGIAGLNYN RNEVLAIQGD 
61:	QISSFVPKEG IQSNGKFIVV ERDKKSLTTS PVDISIVDSI TNRTYPGAIQ LANKDFADNQ 
121:	PSLVMAARKP LDISIDLPGL KNENTISVQN PNYGTVSSAI DQLVSTWGEK YSSTHTLPAR 
181:	LQYAESMVYS QNQISSALNV NAKVLNGTLG IDFNAVANGE KKVMVAAYKQ IFYTVSAGLP 
241:	NNPSDLFDDS VTFAELARKG VSNEAPPLMV SNVAYGRTIY VKLETTSKSN DVQTAFKLLL 
301:	NNPSIQASGQ YKDIYENSSF TAVVLGGDAQ THNQVVTKDF NVIQSVIKDN AQFSSKNPAY 
361:	PISYTSVFLK DNSIAAVHNN TEYIETKTTE YSKGKIKLDH SGAYVAQFEV YWDEFSYDAD 
421:	GQEIVTRKSW DGNWRDRSAH FSTEIPLPPN AKNIRIFARE CTGLAWEWWR TVVDEYNVPL 
481:	ASDINVSIWG TTLYPKSSIT H