TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.C.12.1.8
Suilysin (SLY, a hemolysin) of 497 aas is a pore-forming cholesterol-dependent cytolysin of S. suis and a true virulence factor (Tenenbaum et al. 2016). It plays a role during the development of S. suis meningitis in pigs and humans, and is a potential vaccine candidate.

Accession Number:O85102
Protein Name:Hemolysin
Length:497
Molecular Weight:54778.00
Species:Streptococcus suis [1307]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules, large molecules

Cross database links:

Pfam: PF01289   

Gene Ontology

GO:0015485 F:cholesterol binding
GO:0009405 P:pathogenesis

References (1)

[1] “Hybridization analysis of the gene encoding a hemolysin (suilysin) of Streptococcus suis type 2: evidence for the absence of the gene in some isolates.”  Okwumabua O.et.al.   10564796

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MRKSSHLILS SIVSLALVGV TPLSVLADSK QDINQYFQSL TYGPQEILTN EGEYIDNPPA 
61:	TTGMLENGRF VVLRREKKNI TNNSADIAVI DAKAANIYPG ALLRADQNLL DNNPTLISIA 
121:	RGDLTLSLNL PGLANGDSHT VVNSPTRSTV RTGVNNLLSK WNNTYAGEYG NTQAELQYDE 
181:	TMAYSMSQLK TKFGTSFEKI AVPLDINFDA VNSGEKQVQI VNFKQIYYTV SVDEPESPSK 
241:	LFAEGTTVED LKRNGITDEV PPVYVSSVSY GRSMFIKLET SSRSTQVQAA FKAAIKGVDI 
301:	SGNAEYQDIL KNTSFSAYIF GGDAGSAATV VSGNIETLKK IIEEGARYGK LNPGVPISYS 
361:	TNFVKDNRPA QILSNSEYIE TTSTVHNSSA LTLDHSGAYV AKYNITWEEV SYNEAGEEVW 
421:	EPKAWDKNGV NLTSHWSETI QIPGNARNLH VNIQECTGLA WEWWRTVYDK DLPLVGQRKI 
481:	TIWGTTLYPQ YADEVIE