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1.C.12.1.9
Pyolysin

Accession Number:O31241
Protein Name:PLO
Length:534
Molecular Weight:57873.00
Species:Arcanobacterium pyogenes [1661]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate large molecules, small molecules

Cross database links:

Pfam: PF01289   

Gene Ontology

GO:0015485 F:cholesterol binding
GO:0009405 P:pathogenesis

References (1)

[1] “The Arcanobacterium (Actinomyces) pyogenes hemolysin, pyolysin, is a novel member of the thiol-activated cytolysin family.”  Billington S.J.et.al.   9324258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKRKAFASLV ASVVAAATVT MPTASFAAGL GNSSGLTDGL SAPRASISPT DKVDLKSAQE 
61:	TDETGVDKYI RGLKYDPSGV LAVKGESIEN VPVTKDQLKD GTYTVFKHER KSFNNLRSDI 
121:	SAFDANNAHV YPGALVLANK DLAKGSPTSI GIARAPQTVS VDLPGLVDGK NKVVINNPTK 
181:	SSVTQGLNGL LDGWIQRNSK YPDHAAKISY DETMVTSKRQ LEAKLGLGFE KVSAKLNVDF 
241:	DAIHKRERQV AIASFKQIYY TASVDTPTSP HSVFGPNVTA QDLKDRGVNN KNPLGYISSV 
301:	SYGRQIFVKL ETTSTSNDVQ AAFSGLFKAK FGNLSTEFKA KYADILNKTR ATVYAVGGSA 
361:	RGGVEVATGN IDALKKIIKE ESTYSTKVPA VPVSYAVNFL KDNQLAAVRS SGDYIETTAT 
421:	TYKSGEITFR HGGGYVAKFR LKWDEISYDP QGKEIRTPKT WSGNWAARTL GFRETIQLPA 
481:	NARNIHVEAG EATGLAWDPW WTVINKKNLP LVPHREIVLK GTTLNPWVED NVKS