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1.C.123.1.5
Non-syndromic hearing impairment protein 5, DFNA5, of 496 aas.  It plays a role in hearing loss and the TP53-regulated cellular response to DNA damage, probably by cooperating with TP53 (Masuda et al. 2006; Kim et al. 2008; Op de Beeck et al. 2011). The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity (Ding et al. 2016).

Accession Number:O60443
Protein Name:Non-syndromic hearing impairment protein 5
Length:496
Molecular Weight:54555.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate Solutes

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FASTA formatted sequence
1:	MFAKATRNFL REVDADGDLI AVSNLNDSDK LQLLSLVTKK KRFWCWQRPK YQFLSLTLGD 
61:	VLIEDQFPSP VVVESDFVKY EGKFANHVSG TLETALGKVK LNLGGSSRVE SQSSFGTLRK 
121:	QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC 
181:	GGIVGIQTKT VQVSATEDGN VTKDSNVVLE IPAATTIAYG VIELYVKLDG QFEFCLLRGK 
241:	QGGFENKKRI DSVYLDPLVF REFAFIDMPD AAHGISSQDG PLSVLKQATL LLERNFHPFA 
301:	ELPEPQQTAL SDIFQAVLFD DELLMVLEPV CDDLVSGLSP TVAVLGELKP RQQQDLVAFL 
361:	QLVGCSLQGG CPGPEDAGSK QLFMTAYFLV SALAEMPDSA AALLGTCCKL QIIPTLCHLL 
421:	RALSDDGVSD LEDPTLTPLK DTERFGIVQR LFASADISLE RLKSSVKAVI LKDSKVFPLL 
481:	LCITLNGLCA LGREHS