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1.C.127.1.1
Human Apolipooprotein A1, APOL1, a tripanolytic factor of 398 aas and 4 possible α-helical TMSs in a 1 + 2 + 1 TMS arrangement. Pore-formation has been demonstrated in planar bilayer membranes.  Pore-formation is blocked by the serum resistance-associated VSG protein, SRA. See family discussion for a published description of this protein (Thomson and Finkelstein 2015). APOL1 risk variants induce opening of the mitochondrial permeability transition pore (Carney 2019).

Accession Number:O14791
Protein Name:Apolipoprotein L1
Length:398
Molecular Weight:43974.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Secreted1
Substrate

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEGAALLRVS VLCIWMSALF LGVGVRAEEA GARVQQNVPS GTDTGDPQSK PLGDWAAGTM 
61:	DPESSIFIED AIKYFKEKVS TQNLLLLLTD NEAWNGFVAA AELPRNEADE LRKALDNLAR 
121:	QMIMKDKNWH DKGQQYRNWF LKEFPRLKSE LEDNIRRLRA LADGVQKVHK GTTIANVVSG 
181:	SLSISSGILT LVGMGLAPFT EGGSLVLLEP GMELGITAAL TGITSSTMDY GKKWWTQAQA 
241:	HDLVIKSLDK LKEVREFLGE NISNFLSLAG NTYQLTRGIG KDIRALRRAR ANLQSVPHAS 
301:	ASRPRVTEPI SAESGEQVER VNEPSILEMS RGVKLTDVAP VSFFLVLDVV YLVYESKHLH 
361:	EGAKSETAEE LKKVAQELEE KLNILNNNYK ILQADQEL