TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.C.14.1.7
Phobalysin (Cytolysin; Hemolysin; HlyA, PhlyP ("photobacterial lysin encoded on a plasmid") of 603 aas.  48% identical to The Vibrio cholerae hemolysin (1.C.14.1.1). Forms small β-barrel pores in eukaryotic membranes causing efflux of K+ and ATP but not proteins and entry of Ca2+ and dyes (Rivas et al. 2015; von Hoven et al. 2017).

Accession Number:D1J6Q5
Protein Name:Cytolysin and hemolysin, HlyA, Pore-forming toxin
Length:603
Molecular Weight:68061.00
Species:Photobacterium damselae subsp. damselae [85581]
Number of TMSs:1
Substrate ATP, potassium ions

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MKIRKLYSCI LLGLSSLSAS AIAEVDNYST PADVVSILSS VKNPDRIVYI NMKQEELSTY 
61:	DSILEDIINN DKQYIFDLSF DSDEEKANLQ KKFKDLMGVK FDSNFIVVTG YKNQLMYTPI 
121:	SDTNDRMISI LDHEAKSNDI SKFPRALALS SGKVASDQSI SLPHVSFYLN VNKEITDQEC 
181:	TFRNSLIWDR GSRSFCKNGN ISLIYQVILE RSLSFGTNGV ATPDAKIVRI SLDDNTTGAG 
241:	IHLNDTLTHK SYWANYQVVS GWAREWSASA IAQDYLFDIS TSNEKAQILK TFPRENINSN 
301:	YNINESSGFT IGVTGGAEVS KDGPKASLQA SASYSQSKSL SFNTQDYRVE KNSTSAQNVS 
361:	FRWAREQYPN SESLLDKWTN PVWSEDYPAN LKKVQPLSYA SFVPKLDVIY KASPNETGKT 
421:	QFTIDSSVNI MPLYNRAWFY FYGVGAHQTY YGVDDQPLRR VNKAISFTVD WEHPVFTGGT 
481:	PVNIQLASFN NKCMDIQNKG IVMTAECDIN SKSQSFIYDQ YNRYVSATNT KLCLDGESLS 
541:	ELQPCSLKLT QKWLWDGDKL KNSFEDKYLT FDNDTFLLES SLSNKQKLNS SYTRVFDSST 
601:	INK