TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.C.16.1.1
Magainin precursor of 333 aas and 1 TMS.  3-d structural determinations and simulations show the oligomeric states, transmembrane helices and tilt angles in the various states of the mature Maganin (Pino-Angeles et al. 2016).  Forms stable heterooligomers with PglA (TC# 1.C.16.1.5) at lower concentrations of the two peptides than allows each one alone to form pores in which PglA, rather than magainin 2 forms the pore (Strandberg et al. 2016).

Accession Number:P11006
Protein Name:MAGA
Length:303
Molecular Weight:33380.00
Species:Xenopus laevis (African clawed frog) [8355]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate electrolytes, water, small molecules

Cross database links:

RefSeq: NP_001081306.1   
Entrez Gene ID: 397766   
KEGG: xla:397766   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019835 P:cytolysis
GO:0042742 P:defense response to bacterium
GO:0050832 P:defense response to fungus
GO:0019836 P:hemolysis by symbiont of host erythrocytes

References (4)

[1] “The cDNA sequence coding for prepro-PGS (prepro-magainins) and aspects of the processing of this prepro-polypeptide.”  Terry A.S.et.al.   2833514
[2] “Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.”  Zasloff M.et.al.   3299384
[3] “Antimicrobial peptides in the stomach of Xenopus laevis.”  Moore K.S.et.al.   1717472
[4] “Structure and orientation of the antibiotic peptide magainin in membranes by solid-state nuclear magnetic resonance spectroscopy.”  Bechinger B.et.al.   8298457
Structure:
1D9J   1D9L   1D9M   1D9O   1D9P   1DUM   1F0D   1F0E   1F0F   1F0G   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MFKGLFICSL IAVICANALP QPEASADEDM DEREVRGIGK FLHSAGKFGK AFVGEIMKSK 
61:	RDAEAVGPEA FADEDLDERE VRGIGKFLHS AKKFGKAFVG EIMNSKRDAE AVGPEAFADE 
121:	DLDEREVRGI GKFLHSAKKF GKAFVGEIMN SKRDAEAVGP EAFADEDLDE REVRGIGKFL 
181:	HSAKKFGKAF VGEIMNSKRD AEAVGPEAFA DEDFDEREVR GIGKFLHSAK KFGKAFVGEI 
241:	MNSKRDAEAV GPEAFADEDL DEREVRGIGK FLHSAKKFGK AFVGEIMNSK RDAEAVDDRR 
301:	WVE